Dog days are the hottest and most yang-filled stage in a year, and it is also an important time for health preservation. Various health preservation methods circulating on the Internet, such as drinking hot water in the dog days to force out the cold in the body, eating more mutton and ginger to "heat up" and so on, have also made many people follow suit for many years. So, are these health care methods reliable? Recently, shenyang evening news and Shenbao all-media reporters interviewed a number of health experts on related issues. They said that the principle of TCM health care is to conform to nature and pay attention to people, time and local conditions. Many widely spread health care methods are not necessarily scientific and not necessarily suitable for everyone. People should not fall into misunderstanding and blindly follow.

　　A

　　Myth 1: You can’t eat cold drinks and insist on drinking hot water in the dog days.

　　Some people think that drinking hot water in the dog days can force out the cold that has penetrated into the bone marrow for many years, and you can’t touch a cold drink, otherwise it will damage the yang, destroy human immunity and increase the probability of illness. Is this really the case?

　　Expert analysis: Yuan Renjie, director of the Center for Prevention and Treatment of Diseases of the Fourth People’s Hospital of Shenyang, said that cold and heat are a pair of natural attributes, and they also represent yin and yang, such as "cold and heat are signs of yin and yang" in Huangdi Neijing. A healthy body is "yin and yang are secret, and the spirit is the rule." The most controversial thing about health care in the dog days is that the yang is strong in the dog days, and drinking ice drinks, with the attribute of yin, will hurt the yang, causing the imbalance between yin and yang to be a disease, but this statement is too absolute. Some people do have diarrhea and other symptoms when drinking ice drinks. This is because of the different constitutions. People with yang deficiency are inherently yang-deficient, and drinking yin-cold products makes the deficiency of yang more deficient, so they can’t drink it. So for people with peaceful constitutions, it is not bad to drink a small amount of ice drinks to relieve summer heat. In that case, drinking hot water can force out the cold in the body, in fact, this effect is very small. Hot water can ensure the normal operation of yang on people’s body surface, but the cold in the body is accumulated over time, and there are many reasons for its formation. Drinking hot water alone cannot solve the fundamental problem.

　　B

　　Myth 2: Eat more mutton and ginger in "heating with heat"

　　A health post was circulated in a circle of friends: "A bowl of mutton soup in dog days does not require a doctor to prescribe a prescription", saying that eating mutton and drinking mutton soup in dog days can "heat up, sweat and detoxify". In addition, the same is true of "eating radish in winter and ginger in summer, without a doctor prescribing". So, is it really better to eat these hot foods in the dog days?

　　Expert analysis: this statement is not completely correct. If you understand it incorrectly, you will not achieve the purpose of health preservation, but it will be counterproductive. Ginger and mutton are spicy and hot foods, so people with yin deficiency constitution, damp heat constitution constitution and partial qi stagnation constitution should not eat more. However, for some special people, this way of keeping in good health is very suitable. For example, people who eat too much cold and cold food to relieve summer heat are prone to damage the spleen and stomach and consume yang. Proper eating of some foods that are pungent and cold can eliminate these side effects, which is the meaning of "heating with heat". If you don’t have the habit of eating cold food, or have been eating warm food, or are hot people, the "heating with heat" regimen will only "add fuel to the fire" and cause people to get angry.

　　C

　　Myth # 3: Practice in summer, exercise after three days of rain, and keep cool.

　　Many people think that summer is very cool after rain and suitable for exercise, so they will take a walk after rain, or go out for running and fitness, breathe the air after rain and feel comfortable. In fact, going to exercise after the rain in summer will aggravate the moisture in the body.

　　Expert analysis: "Practicing 39 in winter and three volts in summer" is the experience summarized by predecessors in the long-term exercise process, which makes sense. However, for the elderly, "training for three days in summer" is not suitable. The climate in dog days is characterized by high temperature, low air pressure and high humidity. In this weather, summer is the main way to maintain health, and quietness is to nourish the heart, with more quietness and less movement. Middle-aged and elderly people must not exercise excessively in midsummer, because sweating will lead to blood viscosity, blood volume reduction and other cardiovascular and cerebrovascular diseases. Exercise in the dog days must avoid high temperature and be carried out in a cool place and at a cool time. It is advisable to do gymnastics, walking, Tai Chi and other light exercises, as long as you sweat slightly. It is very fresh to exercise the air after rain, but the relative humidity is relatively high, and dampness is also easy to invade the human body, especially when sweating after exercise and the hair is wide open, it is necessary to prevent dampness from invading.

　　D

　　Myth 4: Prevent heatstroke and catch a cold, and always drink Huoxiang Zhengqi water.

　　Many people carry Huoxiang Zhengqi water with them to prevent heatstroke in summer. However, Huoxiang Zhengqi Water is not suitable for everyone. If the physique is not suitable, taking it blindly will only hurt the body.

　　Expert analysis: The main component of Huoxiang Zhengqi Water is Huoxiang, with Atractylodes lancea, Pericarpium Citri Tangerinae, Magnolia Officinalis, Radix Angelicae Dahuricae, Poria, Pericarpium Arecae, Pinellia ternata, etc., which has the functions of relieving exterior dampness, regulating qi and harmonizing middle energizer. It can be used for treating common cold caused by exogenous wind-cold, internal injury and dampness stagnation or summer injury and summer dampness, with symptoms such as headache, heaviness in chest and diaphragm, abdominal distension and pain, vomiting and diarrhea, etc. When taking it, it needs to be accurate in syndrome differentiation, and it is best to take it under the guidance of pharmacists and doctors. Because the medicine is Xinwenfa powder, it is suitable for patients whose dampness is heavier than heat or cold-dampness. If people with heat-toxic reaction eat Huoxiang Zhengqi, it is equivalent to eating backwards, and the medicine will not only be ineffective but also delay the illness.

　　In addition, Zhao Liren, a health expert at Ministry of Human Resources and Social Security Education and Training Center in China, reminded that Huoxiang Zhengqi Water contains a certain amount of ethanol. If you drink a drink containing ethanol after applying cephalosporins, it will lead to "ethanol accumulation" in the body and a disulfiram-like reaction (also known as sulfur-like reaction of abstinence, which is manifested by symptoms such as facial flushing, headache, abdominal pain, sweating, palpitation and dyspnea). Therefore, be careful not to use cephalosporins when taking Huoxiang Zhengqi Water.

　　E

　　Expert advice: mung bean soup after "transformation" has better health care effect.

　　In hot weather, the cool mung bean soup must be the favorite of many people. Then, do you know why mung bean soup can relieve summer heat? How to decoct and match, and the effect of relieving summer heat is better? Let’s listen to the introduction of health expert Zhao Liren.

　　Drinking mung bean water in summer can effectively stimulate appetite and have the effects of clearing away heat, promoting diuresis, relieving summer heat, cooling blood and detoxifying. It has a good auxiliary treatment effect on sore throat, sore mouth, dry stool, dry mouth and bad breath. The heat-clearing power of mung beans lies in the skin, and the detoxification power is included. Therefore, if you just want to cool off the heat, wash the mung beans when cooking the soup, and boil them with strong fire for about 10 minutes. The soup cooked in this way is green and clear, and has the best effect of cooling off the heat.

　　In addition, cooking mung bean soup with other ingredients will also produce good health effects. For example, mung bean double flower soup: choose 100 grams of mung bean and 10 grams of honeysuckle, and decoct them with water. You can also add Coicis Semen for invigorating spleen and eliminating dampness to make Coicis Semen and mung bean soup, and add Lily for nourishing yin and moistening lung to make Lily and mung bean soup. It should be noted that mung beans are cool, and people with weak constitution and cold are not suitable for drinking. In addition, mung bean also has detoxification function. Therefore, if the drugs taken by patients, whether traditional Chinese medicine or western medicine, contain organic phosphorus, calcium, potassium and other components, mung bean will combine with these components to form a precipitate, thus decomposing the efficacy and affecting the treatment. (Reporter Wang Yuzhe)

　　August

　　Another batch of laws and regulations concerning people’s livelihood are "new"!

　　A series of new regulations to protect the rights and interests of military personnel will be effective.

　　The abuse of "face brushing" technology will be regulated.

　　The phenomenon of electric vehicles entering the building will be punished.

　　… …

　　Which one do you care about most?

　　Further improve the protection of military rights and interests

　　August 1st is the Army Day of the People’s Liberation Army of China, and a number of new regulations related to the rights and interests of military personnel and their families came into effect.

　　The Law on the Protection of the Status and Rights and Interests of Soldiers in People’s Republic of China (PRC) came into effect on August 1,To stipulate the basic treatment enjoyed by soldiers in terms of salary, housing, medical care, insurance, vacation to visit relatives, education and training, and settlement with the army; We will improve the system of pensions and preferential treatment for servicemen, and make provisions on the policies of praise for martyrs, death pensions and disability pensions, as well as preferential treatment for servicemen’s families and martyrs, servicemen who died in the line of duty, and survivors of deceased servicemen in employment placement, children’s education, assistance and assistance, and judicial services.

　　According to the arrangement of the Department of Veterans Affairs and the Ministry of Finance, starting from August 1st, the disabled people (disabled soldiers, disabled people’s police, disabled state functionaries and disabled militia migrant workers), the "three families" (survivors of martyrs, soldiers who died in the line of duty, survivors of deceased soldiers) and the "three reds" (veterans of the Red Army in rural areas, veterans of the Red Army in the West Road Army in rural areas, and the Red Army lost people) will receive living allowances.

　　In addition, the Regulations on Mass Work in the Army, which came into effect on August 1, has improved the working mechanism of coordinating local support for troops in training and preparing for war, organizing support for the army, implementing the preferential policies for supporting the army, and carrying out activities to create a model of "double support".

　　It is infringement for business premises to collect face information without authorization.

　　The widely criticized compulsory "face brushing" problem also has corresponding new regulations:The new judicial interpretation of the Supreme Law, which came into effect on August 1, regulates the abuse of face recognition technology in business premises.According to the Provisions of the Supreme People’s Court on Several Issues Concerning the Application of Laws in the Trial of Personal Information-related Civil Cases, using face recognition technology for face verification, identification or analysis in hotels, shopping malls, banks, stations, airports, stadiums, entertainment places and other business places and public places in violation of laws and administrative regulations is an act that infringes on the personal rights and interests of natural persons.

　　The judicial interpretation is clear. Property service enterprises or other building managers use face recognition as the only verification method for owners or property users to enter and leave the property service area. If the owners or property users who disagree request them to provide other reasonable verification methods, the people’s courts will support them according to law.

　　Integration of value-added tax, consumption tax and additional tax returns

　　According to the new regulations of State Taxation Administration of The People’s Republic of China,From August 1st, when taxpayers declare value-added tax and consumption tax, they should complete the declaration of urban maintenance and construction tax, education surcharge and local education surcharge.

　　This integration is to integrate the VAT tax return (applicable to general taxpayers), VAT tax return (applicable to small-scale taxpayers) and its attached materials, VAT prepaid tax form and consumption tax return with the Urban Maintenance and Construction Tax Education Fee Additional Local Education Additional Return, and to enable the VAT and Additional Taxes Return (applicable to general taxpayers), VAT and Additional Taxes Return (applicable to small-scale taxpayers) and.

　　The integration of declaration forms will realize the sharing of information on value-added tax, consumption tax and additional taxes and fees, and improve the efficiency of declaration; It is conducive to ensuring the quality of declaration and the timely implementation of preferential policies, and reducing the tax burden of taxpayers.

　　Ask them to provide other reasonable verification methods, and the people’s court will support them according to law.

　　The new fire regulations prohibit battery cars from "entering the building"

　　The Regulations on Fire Safety Management of High-rise Civil Buildings came into effect on August 1st, which stipulated the problem of electric vehicles entering the building.

　　The rules are clear,It is forbidden to park or charge electric bicycles in public halls, evacuation walkways, stairwells and safety exits of high-rise civil buildings.Encourage the establishment of centralized storage and charging places for electric bicycles in high-rise residential quarters.

　　In violation of the above provisions, the fire rescue agency shall order it to make corrections. Refuses to correct, the business units and individuals at more than 2000 yuan to 10000 yuan fine, the non-business units and individuals at 500 yuan above 1000 yuan fine.

　　Pork safety supervision is stricter.

　　The newly revised Regulations on the Management of Pig Slaughtering came into effect on August 1st.The regulations require that the pig slaughtering plant should check the information such as pig quarantine certificate according to law, truthfully record the source, quantity, supplier name and contact information of pigs, and ensure the traceability of the source of pigs. In the process of slaughter, meat quality inspection should be carried out simultaneously with pig slaughter, and the inspection results should be recorded truthfully to ensure that the slaughter process is controllable. The pig slaughtering plant shall truthfully record the name, specifications, quarantine certificate number and other contents of the factory pig products to ensure that the whereabouts of the pig products can be checked.

　　The regulations clearly stipulate that pig slaughtering plants should fulfill their obligations such as reporting and recalling in a timely manner, and take measures such as harmless treatment of recalled pig products to ensure that problem products do not flow into the market.

　　High school military training shall not be less than 7 days.

　　The "Military Training Syllabus for Senior High School Students" was implemented nationwide on August 1st.The "Outline" makes it clear that the military training teaching for senior high school students includes two parts: basic military knowledge and basic military skills, and the teaching time is 7 to 14 days, with a total of 56 class hours in no less than 7 days. Among them, there are 24 hours of basic military knowledge, 12 hours of compulsory training and 12 hours of elective training; There are 88 class hours of basic military skills, 44 class hours of compulsory training and 44 class hours of optional training.

　　(Part of the image source: vision china)

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    In recent years, many domestic industrial belts have successively joined the cross-border e-commerce track, and "cross-border e-commerce+industrial belt" has become one of the main forms of foreign trade. In 2024, the domestic industrial belt will face not only the cross-border blue ocean, but also the long-term high-quality sea going. The reporter’s recent visit found that some cross-border e-commerce platforms are helping the industrial belt to expand into a "new blue ocean and new growth pole" through digital means, and promoting the leap of "Made in China" in the international market competitiveness and brand power.

   Cross-border e-commerce empowers industrial belts to expand markets.

    Industrial cluster is an important carrier to promote the high-quality development of regional economy. At present, there are hundreds of light industrial clusters in China, which play an important role in regional economy. In recent years, major cross-border e-commerce platforms have begun to increase cooperation with industrial belts to help local enterprises expand overseas business opportunities more accurately and efficiently through in-depth services.

    In September 2023, Xiyin, a cross-border e-commerce platform, announced the launch of the national 500-city industrial belt plan. Within three years, it will go deep into the national 500-city industrial belt, connect the industrial belt with digital trade and digital flexible supply chain, and provide integrated empowerment from production to market sales to brand growth, helping the industrial belt expand the global market and gain brand promotion. The reporter learned that through the continuous deepening of the 500-city industrial belt going to sea plan under the platform model, the flexible supply chain model of "small single and quick response" produced by Xiyin on demand is splitting from the clothing industry to more industries, helping the industrial belt to go to sea with cross-border e-commerce, and at the same time, empowering this set of capabilities to more industrial belt sellers through platform.

    Going out to sea is not the digestion of excess capacity, but the flexible supply chain makes the market demand and supply more match. By cultivating new models and new formats, the productivity of industrial belts will be improved, and at the same time, small and medium-sized sellers will be realized. In the process of internationalization of China’s manufacturing industry, domestic characteristic industrial belts need to build their own competitive advantages in order to win. With the help of updated digital ideas and digital means, they can realize efficient resource allocation and accelerate innovation, and finally realize the overall capacity transformation and upgrading of industrial belts.

    According to the Insight Report of Cross-border E-commerce Industry 2023 Industry Belt Brand Going to Sea released by Billion Think Tank, "Cross-border E-commerce+Industry Belt" provides a strong impetus for high-quality going to sea. Cross-border e-commerce industrial belts in China have their own characteristics. With the continuous release of policy dividends, many traditional foreign trade industrial belts have achieved global business expansion through cross-border e-commerce.

   From product to brand.

    At present, China’s industrial belt has entered a new stage of intensive brand going out to sea from extensive high-speed growth. Under the background of the state’s support for the development of new foreign trade formats, many traditional foreign trade industrial belts have been actively transformed by relying on cross-border e-commerce channels and digital service tools, further focusing on brand building and global development.

    In the eyes of the industry, one way for the industry to take the brand to the sea is to take the flexible supply chain as the support and embark on the road of brand internationalization through the cross-border e-commerce platform; The other is that trade-oriented businesses transform and upgrade from distributing goods to brands, and build their own brands with the help of cross-border e-commerce platforms.

    Building its own brand and strengthening its brand power are regarded as the inevitable trend of "Made in China". Insiders pointed out that cross-border e-commerce platforms not only empower more industrial belt sellers with flexible supply chain capabilities, but also actively assist industrial belt sellers to build brand power together. The platform helps industrial belt sellers to improve a series of capabilities including product development, market trends, compliance management and supply chain management by empowering them with one-stop services. For the industrial belt, the future is not only the product going out to sea, but also the overall ability and brand power of the industrial belt going out to sea and upgrading. If the industrial belt wants to go to sea, it must achieve high-quality going to sea, and the ultimate benefit will be the comprehensive competitiveness of the whole "Made in China".

    Deng Nan, the seller of wig industry belt, paid attention to the demand of overseas consumers for wigs in his early years. Through the online Xiyin platform, the humble niche products achieved sales of 50,000 US dollars in the first month; Three years later, this number has grown to $2 million.

    "At present, industries driven by cross-border e-commerce platforms are brought out to sea, allowing China’s high-quality supply chain to directly face international consumers, opening up new international markets and promoting industrial upgrading." Zhao Lingyi, chief analyst of Shen Wanhongyuan’s research on commerce and retail, told reporters that the new format of going to sea promoted by "cross-border e-commerce+industrial belt" will further promote the transformation of China’s manufacturing industry into a China brand with independent design concept and strong market competitiveness, thus occupying a more important position in the global value chain.

   Digital innovation drives the development of industrial belt

    Last year, the General Office of the State Council issued an opinion on promoting the stable scale and excellent structure of foreign trade, proposing to support foreign trade enterprises to expand their sales channels and cultivate their own brands through new formats and new models such as cross-border e-commerce, encouraging all localities to combine their industrial and endowment advantages, innovate and build a comprehensive cross-border e-commerce experimental zone, actively develop the "cross-border e-commerce+industrial belt" model, and drive cross-border e-commerce enterprises to export to enterprises.

    Domestic emerging cross-border e-commerce platforms such as Xiyin, AliExpress and Tik Tok Xiaodian have attracted a large number of consumers and sellers through their own characteristics and unique development models, and gradually occupied an important position in the global e-commerce market. In the future, domestic cross-border e-commerce enterprises are expected to fully benefit from the continuous high penetration rate of global e-commerce and the cost-effective advantage of "Made in China" to drive the rapid development of the domestic cross-border e-commerce market. In addition, sellers related to brand going out to sea and manufacturing going out to sea are expected to benefit from the traffic dividend brought by the emerging cross-border e-commerce platform in China.

    "New advantages need to be established in the process of manufacturing internationalization. China’s manufacturing industry must take the road of increasing added value in the future. The added value comes from innovations in design, technology and products, as well as the improvement of brand power. " Hu Qimu, chief researcher of digital economy think tank, said that enterprises can make the supply chain more efficient through digital means, realize personalization and improve overall efficiency at the same time.

    Hu Qimu believes that the "cross-border e-commerce+industrial belt" model is to use digital tools to help businesses continuously optimize the supply chain, solve the problem of production balance through flexible small orders, and then digitally manage the whole process of a large number of fragmented orders, so as to realize flexible and standardized production, improve quality and efficiency, and empower more industrial belts to build new quality productivity and brands to go to sea. (Reporter Gao Shaohua)

Yang Jianfei: Computational Medicine Promotes Accurate Clinical Trials.

　?

Yang Jianfei, Chief Scientific Officer of Zheyuan Technology

Computational medicine needs to be composed of interdisciplinary teams and platforms. By integrating supercomputing system, AI platform, molecular and clinical data, massive literature and biological information, it can realize effective analysis and calculation of drug development and assist decision-making.

Taking an anti-tumor drug in our pipeline as an example, we read all the literatures of the target disease by using the "TWIRLS stick" of the computational medicine platform, first we have all the scientific knowledge known on the earth at present, and then we analyze the digital twins of patients in the patient database in a data-driven way to obtain the disease mechanism, specific targets and "portraits" of patients.

As we all know, the tumor is heterogeneous in time and space, and the immune system around the tumor is particularly complex. Therefore, only by having an accurate "portrait" of the patient’s tumor and accompanying diagnosis can we enter the stage of accurate clinical trials.

Through the computational medical platform, we established the response mechanism model of CDK4/6 inhibitor, and the effectiveness of this model was verified by the data of TCGA and Chinese patients. Then we put this drug currently used to treat breast cancer on the computational medical platform to study whether it has other applicable diseases. It was found that the model score of chordoma was very high, so we established cooperation with shanghai changzheng hospital and saw that some patients achieved partial remission in the third week after taking the drug. Although this drug has not yet entered the clinical trial stage, as long as it is carried out in accordance with the norms of computational medicine platform, we are confident to achieve truly accurate clinical trials.

Peng Ao: Behind the clinical success rate from 2% to 21%

Peng Ao, Project Management Team Leader of Pfizer China Product Line

The efficiency of Pfizer’s new drug research and development has increased from 2% to 21%. I think we can sum up three experiences. First, accurate positioning, clear their own specific advantages in the field of biology. Pfizer currently focuses on internal medicine, immunity and inflammation, oncology drugs and vaccines. Second, choose the drug mode. At present, more complex and novel molecular entities account for more and more in our pipelines. Thirdly, the decision-making adheres to two principles. First, quantitative POM analysis is carried out in the first and second phase of the experiment, which can help the success rate of the second phase reach 40%; The second is to plan again. If the first direction of clinical research and development fails, then we will transform it and try again in another direction. If there is a very clear biological basis, our success rate can reach 31%.

Ertuglifozin is a SGLT-2 hypoglycemic agent, and a large number of technologies and methods related to computational medicine are used in its research and development, including systematic pharmacological model and Emax Model. Using this model, the highest hypoglycemic effect of the drug can reach 77%. Meta-analysis shows that the drug has the highest hypoglycemic level among similar products. This is a typical case of using model or computational medicine to guide drug research and development.

The US Food and Drug Administration has begun to build a framework for digital health tools. I believe that after the introduction of the framework, the guiding principles of the corresponding rules will also be introduced, which will guide the application of some new drug research and development more specifically and deeply.

Tang Yu: The insights generated by computational medicine need to be verified clinically.

Tang Yu, Executive Director of the Office of Drug Clinical Trial Research Center, Cancer Hospital, China Academy of Medical Sciences

Computational medicine has produced a large number of insights by analyzing massive data, but how to prove that these insights are authentic and can be used in clinical practice through clinical trials?

The first case is to verify the specific answer given by computational medicine to a specific problem, such as verifying whether the first innovative drug under the guidance of AI can treat pancreatic cancer. The second is based on massive data to verify whether the treatment mode formulated by AI for individual patients or groups is better.

In the course of such an experiment, we need to consider several issues:

First, the consistency of the AI model. When we want to prove that an algorithm or an AI-based paradigm can guide medical care, we must ensure the consistency of the paradigm and not make it change irregularly.　

Second, it is necessary to consider whether there is an accessible clinical treatment for a class of patients with more concentrated biological characteristics found by AI model. If there is no targeted treatment, although this model can guide the prognosis of patients, it is difficult to change the existing treatment methods.

Finally, establish a model that can not only explain the results, but also explain the mechanism, so as to better combine human wisdom with the wisdom of computer based on data integration.

At present, we are carrying out an umbrella research design, focusing on soft tissue sarcoma. Although the overall incidence of the disease is not high, there are nearly 100 subtypes. Our anti-vascular targeted drugs have shown excellent effects in individual subtypes, but the overall effect is still not ideal. Therefore, we hope to use Turing Darwin’s laboratory’s in-depth analysis of the whole sarcoma mechanism and digital twin technology to find drugs with ideal curative effect and high accessibility.

Niu gang: the big disease model changes the new paradigm of drug research and development

Niu Gang, Director of Turing Darwin Laboratory

In today’s medical field, we are committed to collecting and utilizing all kinds of disease-related data, looking for clues of logical unity for diseases, and establishing complex and real mechanism portraits. But the key lies in how to understand the so-called mechanism and who is the subject of the complex mechanism?

We have built and trained a brand-new AI method-"Genome Shotgun Damage Assessment Process" (DAGG). By inputting the sequence information of human germ line or tumor genome, AI can translate the sequence gobbledygook that human can’t understand into understandable changes in cell function.

According to the information of genome variation, clinicians can use DAGG to judge whether HER2 gene is amplified in tumor cells of breast cancer patients, so as to further clarify the pathological types of patients and provide clearer and more accurate judgments for patients’ diagnosis and treatment.

With the DAGG method, we can also transform the real patient data into the digital twins of the patient and his disease. With the large-scale accumulation of patients’ digital twins in virtual environment, we conducted a large-scale virtual clinical trial for PD-1/PD-L1 monoclonal antibodies. The results showed that the efficacy of most immunodrugs with indications was not ideal.

Therefore, the virtual clinical trial based on digital twins can replace the original clinical trial results that cost tens of billions of dollars. Based on the curative effect data of a small sample of individual indications, the potential indications of other tumor diseases can be inferred. At the same time, according to the biological mechanism directly suggested by the model, the combination scheme and even new molecules can be rationally designed, which saves many clinical development steps and costs and ensures greater benefits for patients.

Shi Rong: Computational Medicine Helps Accurate Diagnosis and Treatment of Breast Cancer

Shi Rong, Secretary General of Cancer Prevention and Treatment Committee of Wu Jieping Medical Foundation.

Breast cancer is the largest cancer in the world. HER2 is a definite prognostic indicator and a predictive indicator of drug treatment effect for breast cancer, but the tumor heterogeneity of HER2 expression is obvious, and the detection method of HER2 can not meet the demand of anti-HER2 treatment. Therefore, studying the etiology of the germ line carried in the germ line genome is not only helpful to deeply understand the pathogenesis of breast cancer, but also helpful to develop new methods and provide prospective judgment for subsequent treatment.

Recently, the artificial intelligence algorithm DAGG independently developed by the computational medicine team revealed the pathogenesis of breast cancer. It is found that the signal pathway function spectrum (APSP) can be obtained by using the DAGG model based on the germline fingerprint rare coding variation data. According to the difference in the distribution of APSP between patients and people with low etiology, a prediction model can be effectively constructed to evaluate the etiological risk of female individuals, and the HER2-positive and HER2-negative breast cancer patients can be effectively distinguished.

The clinical transformation path of breast cancer based on APSP is divided into three steps. The first step is to guide the clinical treatment plan based on the pathological classification of breast cancer by APSP. The second step, based on APSP, is the extremely early diagnosis of women with breast nodules and breast cancer with familial breast cancer genetic history, so as to reduce the proportion of breast cancer patients who enter advanced and advanced stages at the first diagnosis. The third step, breast cancer risk assessment of healthy population based on APSP, fills the gap of the lack of effective primary prevention measures for breast cancer in the world.

Jiang Min: Virtual clinical trial is a new paradigm in the future.

Jiang Min, Director of the Office of National Drug Clinical Trial Institution of Peking University Cancer Hospital

From a global perspective, there have been exploratory studies on virtual clinical trials, but retrospective cases are the main ones. Regarding whether we can carry out prospective virtual trial design and generate higher-level digital evidence to verify the computer simulation model, so as to better guide clinical research, Peking University Cancer Hospital and the computational medicine team collided from the perspectives of technology and experimental requirements, forming a real landing research.

The two sides jointly carried out a parallel virtual clinical research project by using the digital twin model of patients in computational medicine. The purpose of the research is to explore the relationship between the pathogenesis of tumor and the mechanism of anti-tumor drugs. Through the virtual clinical trial, the curative effect of anti-tumor drugs is predicted, and the characteristics and differences of patients are analyzed, so as to optimize the design of clinical trials. This study compares head-to-head with a real clinical study of registered new drugs to verify the consistency between the predicted results of virtual clinical research and the curative effects of real-world clinical trials.

Virtual clinical trial is a new paradigm in the future. With the support of computational medicine technology, the future clinical trial model may be transformed into more accurate clinical trial design, which will bring a more holistic drug research and development idea, which will bring revolutionary changes to the success rate and effectiveness of clinical trials.

Roundtable Forum I: Cognition and Evaluation of Non-consensus and Subversive Technology

Moderator: Li Lei, Associate Research Fellow of Frontier Science and Education Bureau of China Academy of Sciences.

Roundtable forum site.

Lv Benfu (Professor, School of Economics and Management, Chinese Academy of Sciences)The so-called breakthrough innovation mainly depends on three points. First, whether a brand-new track has been developed; Secondly, on the original track, whether its performance-to-value ratio conforms to the law of ten times speed; Third, whether it belongs to the pattern innovation from 0 to 1 depends on the support of industrial policies.

Gu Chengming (Head of Sanofi Greater China Medical Department)The non-consensus stage is the primary stage. As long as it is accepted by the industry, it is considered as consensus, or it is available, which can solve some problems. However, in the field of drug research and development, if you want to be a First-in-Class, it must be a non-consensus. If you become a consensus, it will be Me too.

Zhang Chunming (Vice President of the Western Research Institute of Computing Technology, Zhongke)From a practical point of view, today’s world structure does not support small steps forward, and we must give full play to the ability of large-scale team operations. In terms of innovation, it is indeed possible for computational medicine to open up a brand-new track, so any government department should carefully evaluate it.

Weng Huajian (deputy head of Changning District, Shanghai)In 2021, I first learned about computational medicine. At that time, we envisaged to set up a life science innovation center between Suzhou and Shanghai, specializing in high-end research and development, focusing on computer +Inside and AI+, so as to give full play to the accumulation of digital economy in Changning, Shanghai in the past 20 years, especially the accumulation advantages of talents and innovation ecology. Therefore, from the perspective of the government, we are full of expectations for disruptive innovation technology in computational medicine.

Roundtable Forum II: Investment Logic from the Perspective of Computational Medicine

Moderator: translated by Hu Ming, partner of Mingde Capital.

Roundtable forum site.

Tian Feng (Minister of Industry Service Department of Shanghai Biomedical Industry Promotion Center)The most noteworthy point of the whole AI+ pharmaceutical industry is to change from logical successful practice to probabilistic successful practice, and finally return to logical successful practice. From the perspective of AI+ diseases, developing virtual clinical trials, I think it can effectively reduce the cost of clinical development and improve the success rate in the future.

Jing Xutian (Managing Director of Wuyuan Capital): AI technology has brought some new algorithms and breakthroughs in computing power. In the past, many AI pharmaceutical companies paid more attention to the field of small molecules with the most data and the most mature data, but today we see that more and more algorithms are actually very suitable for doing some new modal drug discovery.

Zeng Yingzhe (Partner of Linear Capital)Before AI technology, we usually build low-dimensional models to solve high-dimensional problems, but the emergence of AI can solve these high-dimensional problems. With more and more data and more powerful computing power, the prospect of AI pharmaceutical is very broad. At present, we are observing what progress the big language model will bring to AI pharmaceutical. It is exciting that some new progress has been made in the field of molecular characterization algorithms.

Ma Rui (partner of Fengrui Capital)We always overestimate the progress of computational medicine in five years, but underestimate the progress it can bring in ten years. I think that in the next three years, macromolecular protein drugs will basically be subverted by AI, just like AlphaFold in 2021 completely solved the problem of structural prediction of single domain proteins. (Photo courtesy of the organizer)

CCTV News:The State Council Press Office held a series of press conferences on promoting high-quality development on the 29th. China National Intellectual Property Administration introduces new measures for trademark application of service business entities.

As of June this year, the number of valid registered trademarks in China has reached 45.909 million, with an average of one valid trademark for every four business entities.

In order to meet the diversified trademark application needs of business entities, China National Intellectual Property Administration has set up 353 trademark business acceptance windows in 31 provinces (autonomous regions and municipalities) to provide face-to-face application and consulting services.

Hu Wenhui, deputy director of China National Intellectual Property Administration, said: "At the same time, we actively promote the electronic processing of the whole process of trademark business, optimize the user experience of online application, and discount the online application fee. At present, the online application rate of trademark registration application has reached 99.7%."

In addition, China has realized the electronization of trademark certificates to meet the application needs of mutual recognition of electronic certificates throughout the country. Strengthen the sharing of enterprise registration data and trademark registration data, and realize the synchronous acceptance and collaborative processing of enterprise change registration and trademark change application in many places.

China National Intellectual Property Administration: In the first half of the year, the intellectual property business developed steadily.

In addition, China National Intellectual Property Administration introduced on the 29th that in the first half of the year, China’s intellectual property industry developed steadily.

In the first half of this year, China authorized 554,000 invention patents, a year-on-year increase of 28.0%; There were 2.463 million registered trademarks, a year-on-year increase of 22.0%.

Ge Shu, deputy director of China National Intellectual Property Administration Patent Office, said: "The number of patent transfer licenses nationwide reached 252,000, up 35.2% year-on-year. The registered amount of patent and trademark pledge financing reached 419.9 billion yuan, a year-on-year increase of 57%, benefiting more than 20,000 enterprises. "

In addition, China issued the Implementation Plan for the Construction Project of Intellectual Property Protection System, with protection centers and fast rights protection centers covering 28 provinces (autonomous regions and municipalities), and handled 21,000 administrative cases of patent infringement disputes in the first half of the year, and the protection of intellectual property rights continued to increase.

　　General Secretary of the Supreme Leader pointed out at the National Ecological Environmental Protection Conference: "Deepen the application of digital technologies such as artificial intelligence, build a beautiful digital governance system in China, and build a green and intelligent digital ecological civilization." At present, the integration and mutual promotion of digitalization and greening has become an important theme of global development. To promote the intelligent management of ecological environment and the construction of digital ecological civilization with green wisdom, we must adhere to the guidance of Socialism with Chinese characteristics Thought of the Supreme Leader in the new era, comprehensively implement the ecological civilization thought of the Supreme Leader, promote the comprehensive green transformation of economic and social development with digitalization, and provide strong support for the modernization of harmonious coexistence between man and nature.

　　The integration of digitalization and greening has become an important trend in the construction of ecological civilization.

　　Ecological civilization construction covers a wide range and is comprehensive, involving many aspects such as value concept, goal orientation, production and consumption mode, etc. It is a complex systematic project. Promoting the construction of digital ecological civilization can effectively enhance the systematicness and synergy of ecological civilization construction, and promote the formation of scientific and efficient methods and paths to solve ecological environment problems and expand ecological environment governance.

　　As a way of ecological environment governance, digital ecological civilization construction organically embeds big data, 5G, artificial intelligence and other digital technologies into ecological civilization construction, and continuously improves the scientific, refined and intelligent level of ecological civilization construction in the deep integration of digitalization and greening. The key to building digital ecological civilization lies in coordinating the relationship between digitalization and greening, and promoting their mutual promotion and coordinated development. Promoting digital construction, using artificial intelligence and other technologies to discover the laws behind the data, and fully releasing the superposition, aggregation and multiplication effects of digital technology in improving the efficiency, technological improvement and means optimization of ecological environment governance can provide an important engine for ecological environment governance and help to achieve efficient and sustainable ecological environment governance effects. Promoting green development is the proper meaning of building digital ecological civilization. By optimizing the spatial layout of the country, improving the utilization efficiency of resources and energy, strengthening environmental protection and ecological restoration, focusing on solving problems such as environmental pollution and ecological damage in the development process, matching resources, production, consumption and other factors is conducive to the simultaneous advancement of high-quality development and high-level protection.

　　Since the 18th National Congress of the Communist Party of China, under the guidance of the Supreme Leader’s New Era Socialism with Chinese characteristics Thought, especially the Supreme Leader’s Ecological Civilization Thought, China’s digital ecological civilization construction has made great progress, and the level of intelligent management of ecological environment has been significantly improved. In February this year, the CPC Central Committee and the State Council issued the Overall Layout Plan for the Construction of Digital China, which made "positive progress in the construction of digital ecological civilization" as an important goal for the construction of digital China in 2025, and put forward new requirements for the new generation of digital technology to help ecological governance. In the process of promoting the deep integration of digitalization and greening, China’s energy consumption in the whole chain has been significantly reduced, production efficiency and energy efficiency have been continuously improved, and the ecological benefits and economic and social benefits of green mountains have been continuously brought into play. At the same time, we should also realize that the construction of digital ecological civilization in China is still in its infancy, and there are still some problems to be solved in the construction of digital infrastructure, the construction of data standards and norms, the transformation and application of scientific and technological achievements, and the cultivation of digital ecological civilization talents. We should pay more attention to the use of digital technology to innovate the way of ecological civilization construction, constantly promote the deep integration of digitalization and greening, lead greening with digitalization, drive digitalization with greening, focus on strengthening the collection, adaptation, reconstruction and sharing of ecological environment big data, fully release the potential and vitality of ecological environment governance through digital ecological environment technological innovation, and provide strong kinetic energy for building a beautiful China.

　　Provide strong kinetic energy for the modernization of harmonious coexistence between man and nature.

　　The General Secretary of the Supreme Leader stressed: "We must plan development from the height of harmonious coexistence between man and nature, constantly shape new kinetic energy and advantages of development through high-level environmental protection, and strive to build a green and low-carbon circular economy system, effectively reduce the resource and environmental costs of development, and continuously enhance the potential and stamina of development." Building a green and intelligent digital ecological civilization provides strong technical support for accurate identification, real-time tracking of environmental data, timely judgment and systematic solution of ecological problems, and provides strong kinetic energy for promoting a comprehensive green transformation of economic and social development and building a harmonious coexistence between man and nature.

　　Effectively improve the level of intelligent governance of the ecological environment. Building a digital ecological civilization, integrating ecological environment data into digital technologies such as artificial intelligence, and constantly strengthening machine learning and training will not only help to analyze the historical evolution process of ecological environment more scientifically, but also provide important decision-making reference for timely judgment and systematic solution of ecological environment problems in pollution warning, duration prediction and emission reduction effect prediction, and promote the change of decision-making process from "empirical judgment" to "data analysis", making ecological environment governance more "smart" For example, in the Great Protection of the Yangtze River, the relevant departments have established a "data collection and management —" by building a monitoring network of the whole basin’s ecological environment from Qinghai to Shanghai, collecting and sorting out massive ecological environment data in the Yangtze River basin, developing and integrating water quality diagnosis, forecasting and early warning, pollution traceability, scenario simulation and other functions. Data Mining and Simulation — Virtual visualization — Analysis of pollution traceability — The digital management business system of water environment based on intelligent decision-making provides an important technical guarantee for realizing "one river with clear water flowing eastward".

　　Promote the transformation of ecological environment governance to synergy. In the past, due to the insufficient sharing of ecological environment data and information among regions, departments and units, the ecological environment governance has been fragmented to some extent, and the problem of "repeated governance and repeated governance" in some local ecological environment governance is more prominent. Building a digital ecological civilization and building a "network" of ecological environment data will help to break down data barriers, realize data interconnection, and consolidate the data foundation for the transformation of ecological environment governance paradigm from fragmentation and fragmentation to synergy and integrity. For example, in the response to heavily polluted weather, we should follow the general policy of holistic and whole-process collaborative governance, promote the sharing of basic data among relevant government departments, different scientific research institutions and different disciplines, carry out collaborative research on key areas and key issues, and scientifically put forward the timetable and roadmap for continuous improvement of air quality, so as to provide support for the realization of "blue sky, white clouds and twinkling stars".

　　Accelerate the pace of green and low carbon transformation. Digital technology, represented by a new generation of artificial intelligence, is accelerating the evolution of global scientific and technological revolution and industrial transformation, and promoting the reform of global governance system. Digitalization empowers the construction of ecological civilization and has the efficiency of "1+1>2". Intelligent manufacturing technology strengthens the data analysis ability of manufacturing enterprises in process, manufacturing, logistics and other aspects, and reduces the pollutant emission and carbon emission of product manufacturing; Smart energy system explores the data value of energy production, transmission, distribution, storage and other links, monitors and adjusts energy generation in real time, and improves the utilization efficiency of renewable energy; By establishing a carbon inclusive platform for green living, smart cities will count individual emission reductions into individual carbon assets and turn intangible green behaviors into tangible green values. To promote high-quality economic and social development, we need to keep up with the development trend of world science and technology, embrace digital technology, further improve the endogenous driving force of green and low-carbon transformation of production and lifestyle, and make economic and social development have higher green content, lower carbon content and more gold content.

　　Deepen the application of digital technology in the field of ecological environment

　　The construction of digital ecological civilization can focus on platform construction, data mining, digital intelligence integration, policy guarantee and other aspects to form a "network" and a "map", research and develop data value mining algorithms, promote the deep application of digital technology in the field of ecological environment, and give full play to the basic and leading role of digital ecological environment technology in the construction of beautiful China.

　　Improve the stereoscopic intelligence perception of the sky "a net". The collection and transmission of information is the key link in the construction of digital ecological civilization. At present, it is necessary to do a good job in the top-level design of digital ecological civilization infrastructure construction, build a three-dimensional multi-source monitoring and sensing network system for ecological environment, strengthen the application of big data acquisition technologies such as satellite remote sensing, aerial photography of unmanned aerial vehicles, automatic ground monitoring stations, underwater robots and the Internet of Things, continuously expand the accuracy and space-time breadth of monitoring, and build a multi-means comprehensive and fast-responding monitoring network covering various environmental elements of the atmosphere, water, soil, ecology and ocean to realize global monitoring and sensing of ecological environment elements. Strengthen the construction of digital infrastructure that adapts to intelligent decision-making and green development, and build an "information high-speed rail" for the safe and rapid circulation of ecological environment data, laying a solid foundation for the rapid and accurate use of data.

　　Form a "one map" of national ecological environment data. Data is the key to the construction of digital ecological civilization, but fragmented data can’t play its value. To speed up the collection of eco-environmental data, on the one hand, it is necessary to promote the collection and exchange of eco-environmental data, and realize the cross-level communication and cross-departmental sharing of eco-environmental monitoring and monitoring data and their related information. Comprehensively collect environmental data such as environmental quality, pollution sources, sewage outlets, and ecological environment functional zoning, and promote coordinated management, precise management, and overall improvement of regional ecological environment with resource sharing, complementary advantages, and mutual benefit, so that the data can "run" out of great value. At the same time, strengthen data connectivity with natural resources, water conservancy, meteorology, energy, agriculture, forestry, transportation and other fields, and promote multi-source data integration. On the other hand, it is necessary to firmly grasp the standard, improve the standard system for the collection, integration, classification, sharing and application of eco-environmental data, and actively promote the formulation of digital international standards in the field of eco-environment, so as to contribute to building a green "Belt and Road" and building a global ecological civilization.

　　Develop a value mining algorithm for massive data. The model is the golden key to open the data treasure mine. It is necessary to make full use of digital technologies such as augmented reality and artificial intelligence, strengthen large-scale model simulation, form a more comprehensive and scientific understanding of the evolution of ecological environment and the causes of pollution, and provide multi-dimensional data analysis, early warning and forecasting, and traceability for scientific decision-making and precise governance. Using big data analysis, artificial intelligence, visualization and other technologies, we will strengthen the research and development of digital technologies such as intelligent perception and sharing, fusion and deduction, characterization and expression of environmental data, and inject wisdom genes into key areas such as ecological environment monitoring and early warning, integrated protection and system management of grass and sand in mountains, rivers, forests, fields and lakes, comprehensive prevention and control of multi-media environmental pollution, solid waste reduction and resource utilization, new pollutant control, and response to climate change, and continuously enrich the application scenarios of digital technologies in the field of ecological environmental protection.

　　Promote digital technology to be embedded in the whole process of environmental governance. The deep integration of digital technology and environmental governance has greatly improved the modernization level of ecological environmental governance. Give full play to the advantages of digital technology in breaking through the limitation of information time and space, smooth the interactive channels across regions, levels and departments, gather the strength and wisdom of the government, enterprises and the public, promote the formation of a networked and open multi-collaborative governance pattern, and integrate digital technology into the whole business and life-cycle management of ecological environment such as monitoring and evaluation, supervision and law enforcement, so as to improve the efficiency of environmental governance. Leading green development with digital transformation and optimization of ecological environment management, promoting the transformation and upgrading of industries such as steel, coal, electricity, chemicals and building materials, improving green total factor productivity, reducing energy and material consumption in the whole chain, and promoting the organic unity of economic benefits and ecological benefits.

　　Lay a good job in policies, talents and combination boxing. Constantly improve the policy system that is conducive to the deep integration of digital technology and ecological civilization construction, dismantle the barrier between the environmental governance side and the technology supply side, and create an innovative environment where major digital scientific and technological achievements in the ecological environment field are constantly emerging. Strengthen the research on relevant laws, regulations and policies, and strengthen the open sharing of data on the premise of ensuring data security. Cultivate and introduce compound cross-border talents with professional knowledge in digital technology and ecological environment, and form a three-dimensional and high-level echelon of digital technology talents in ecological environment. We will build a scientific research management system and mechanism conducive to the breakthrough of the core technology of digital ecological civilization, establish and improve a market-oriented diversified investment model, and increase support for digital strategic frontiers and applied basic research in the field of ecological environment.

　　(The author is Dean of china environmental science Research Institute)

　　From 0: 00 on July 12th to 24: 00 on 14th, Yunnan Menglian Dai, Lahu and Wa Autonomous County carried out a general survey of free nucleic acid detection for all employees, and more than 150,000 people were detected, all of which were negative. Immediately, Menglian County lifted the county’s closed management and resumed normal production and living order. However, when entering and leaving Menglian Card Point, it will continue to strictly enforce that all people leaving Menglian must hold a negative certificate of valid nucleic acid test within 3 days, check their ID cards, scan the code bright (that is, scan Yunnan health code and communication big data travel card), and measure their body temperature without abnormality before they can travel; Personnel from high school risk areas or those who have lived in middle and high risk areas in the past 14 days are suspended from entering Bangladesh. If it is really necessary to enter Bangladesh, negative proof of nucleic acid test within 3 days is required; Persons from other provinces (especially key provinces, cities and districts of telecom fraud) who intend to enter Bangladesh without justifiable reasons (unable to provide valid certificates such as business license, real estate certificate, residence permit, enterprises, institutions and villages (communities)) will be persuaded to return. (CCTV reporter Li Jinsong)

In this era of information explosion, the star’s every move is closely watched. Recently, Wang Baoqiang has once again become the focus, and has been involved in the whirlpool of public opinion because of its charity storm and the subsequent’ fraud door’. Why did this actor, who was once considered to be the most human in the entertainment circle, fall into so many controversies? This article will take you to explore the ins and outs of this incident, and let us unveil the truth together.

First, a wonderful beginning: Wang Baoqiang’s "roller coaster" life

Wang Baoqiang’s career is full of ups and downs and glory. From an ordinary farmer to today’s "Billion Film Emperor", he has won numerous applause with his strength. However, in just a few months, he seems to be on the "roller coaster" in the entertainment industry. In October, the news about the collapse of his charity was shocking; Then, in November, there was a "fraud door" with an amount as high as 100 million, which was unbelievable. This series of events seems to imply that Wang Baoqiang is experiencing an unprecedented crisis in the entertainment circle.

Second, the charity storm: people set the fuse for collapse

The cause of the incident originated on October 28th, when a well-known entertainment story revealed that Wang Baoqiang was suspected of charity fraud during the filming of The Octagonal Cage, saying that his image was actually hypocritical. The "little actor"’ s careless complaint quickly triggered a hot discussion among netizens. He not only described the hard life during the filming, but also claimed that Wang Baoqiang’s promise to support school was not fulfilled. For a time, Wang Baoqiang’s "charity design" was hit hard, and many netizens questioned it.

Third, reverse the plot: reveal the true intention of Wang Baoqiang.

With the development of the incident, more truths gradually surfaced. Netizens took the initiative to refute rumors and revealed Wang Baoqiang’s promise to the little actor after the filming. He not only paid 150,000 yuan for each young actor, but also promised to help them finish their studies. Obviously, the opposition did not completely overthrow the true image of Wang Baoqiang, but made things dramatically reversed. More netizens suggested that the careless complaint was not credible, because he already had a considerable economic base, and there were many luxuries in his social account.

Fourth, characterization: Wang Baoqiang’s truth and emotion.

In the entertainment circle, Wang Baoqiang’s truthfulness and simplicity are one of the reasons why he attracts many supporters. Even in the process of his ex-wife Ma Rong absconding with money, Wang Baoqiang still showed his indomitable personality, which made many people feel sympathy for him. In this storm, many supporters have come forward to speak for him, thinking that he has always been a trustworthy person. The hardships of Wang Baoqiang’s childhood life and the story of realizing his dream through hard work later made his image deeply rooted in the minds of many audiences.

V. Fashion and Trend: The Unknown Side of Wang Baoqiang

Although Wang Baoqiang’s recent negative news has dominated the limelight, his performance in the fashion world should not be underestimated. What Wang Baoqiang wears in public often reflects his love for life and his unique understanding of fashion. In the recent red carpet activities, he appeared in a simple but stylish suit and won wide acclaim at the scene. Whether you choose classic black and white collocation or try trendy accessories, Wang Baoqiang can always give people a bright feeling. His fashion concept may not be understood by everyone, but this uniqueness makes him stand out among many stars.

Vi. Hot discussion on social media: the interaction between fans and the public

With the popularity of social media, the interaction between stars and fans has become more frequent. On Wang Baoqiang’s social platform, fans have expressed their views on his events, and the debate between supporters and opponents seems to be endless. Many netizens share their opinions in the comment area, which makes the topic more heated by the coexistence of humor and rationality. It is this kind of interaction that strengthens the connection between Wang Baoqiang and his fans, and also makes this storm the focus of hot discussion on the Internet.

Seven, multi-angle analysis: the opinions of experts and the reactions of ordinary audiences.

For this incident, many industry experts have expressed their views. Some film critics pointed out that the gradual collapse of Wang Baoqiang was not accidental, but the result of the changeable entertainment style and complicated public opinion environment. They believe that once the image of public figures is deeply excavated, it may be greatly reversed. The general audience’s reaction to this incident was polarized. Some viewers said they no longer believed in Wang Baoqiang, while others thought it was just a misunderstanding and needed to give Wang Baoqiang support and understanding.

Eight, the future direction of the event: the story to be continued

Although Wang Baoqiang is facing severe public opinion challenges at present, from the feedback of all parties, things may not have reached the end. With the further development of related events, it will take time to test whether Wang Baoqiang’s personnel structure can be reshaped. No matter how this matter develops, every journey Wang Baoqiang has experienced tells us that the story behind the stars is often more complicated than the characters on the screen.

Generally speaking, this incident in Wang Baoqiang reveals the difficulty and complexity behind the glamorous appearance of the entertainment circle. The construction of a star’s personality requires both talent and hard work, but also persistence and truthfulness. We expect Wang Baoqiang to continue to bring more wonderful works to the audience after the storm, and hope to show a more authentic self in the process.

Editor in charge:

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