CCTV News:On August 29th, the website of Shenyang Municipal Government reported that the epidemic prevention and control headquarters of COVID-19 in Shenyang announced that at present, many cases of people with abnormal nucleic acid test results were found in the regional nucleic acid screening in Shenyang. In order to resolutely and effectively block the spread of the epidemic, effectively protect people’s life safety and health, and reduce the risk of epidemic spread caused by the flow and gathering of people, the relevant measures for strict epidemic prevention and control are hereby announced as follows:

　　First, strict prevention and control measures during regional nucleic acid detection

　　From 0: 00 on August 30 to 24: 00 on September 5, the city continuously carried out regional nucleic acid testing.

　　1. All the people living in Shenyang, before sampling, remain relatively static in their places of residence. According to the unified deployment of the epidemic prevention and control headquarters of each district, county (city) and the organizational arrangement of streets (towns) and communities (villages), nucleic acid testing will be carried out in an orderly manner, and no one will be missed. Only after participating in the nucleic acid sampling can people go to work, go to school and arrange necessary travel.

　　2. The citizens should consciously obey the community (village) organization and on-site management, do personal protection throughout the process, keep a distance of more than 1.5 meters with others, and do not cut in line, talk or gather.

　　3. From now on, the effective time limit of "Liaoshitong" health code will be adjusted from 72 hours to 48 hours. Those who fail to participate in nucleic acid testing within the prescribed time limit will be given a "yellow code" for their health code, and those who cause the spread of the epidemic will be held accountable according to law.

　　4. Shopping malls, supermarkets, hotels, scenic spots, farmers’ markets and other public places with dense personnel, closed space and prone to cluster epidemics shall strictly implement the epidemic prevention and control requirements such as limited quantity and peak shifting, and the number of customers accepted shall not exceed 50% of the maximum carrying capacity.

　　5. Closed public places such as theaters, bath centers, massage parlors, beauty salons, gymnasiums, chess rooms, secret rooms, entertainment halls, cultural centers (stations), Internet cafes, indoor scenic spots, KTV, dance halls, discos, performance venues, and direct sales experience venues are temporarily closed; Night markets, flower and bird markets, and large rural gatherings will be closed in the morning and evening; Restaurants Restaurants are suspended from eating.

　　6. Party and government organs, enterprises and institutions at all levels shall implement "two points and one line", fully implement measures such as nucleic acid detection and health monitoring, and urge them to go to the nearest fever clinic for investigation if abnormal symptoms are found. Advocate qualified citizens to work at home as much as possible and reduce the flow of people.

　　7 welfare institutions, pension institutions, mental health institutions, public security and judicial administrative supervision institutions and other temporary closed management, stop unnecessary visits.

　　8. Primary and secondary schools, kindergartens and off-campus training institutions temporarily stop offline teaching.

　　9. All kinds of public transport vehicles must be disinfected and ventilated, and the drivers and passengers should strictly protect themselves and conduct nucleic acid testing in accordance with industry regulations. Take public transport must strictly check the "four-piece set" (code scanning, temperature measurement, wearing a mask, negative proof of 48-hour nucleic acid test), and the passengers in the car shall not exceed 50% of the rated passenger capacity.

　　10. The city’s long-distance buses and tourist chartered buses (excluding those returning to other cities) are suspended from operation, and the buses and subways (light rail) in the nine urban areas of the city are operating normally during the morning and evening peak hours (6: 00 to 8: 30, 16: 30 to 19: 00), and the interval between vehicles during the peak hours is doubled as that during the daily peak hours.

　　11. Carefully organize large-scale meetings, forums, exhibitions, sales promotions and other personnel gathering activities. If it can be postponed, it will be postponed, and if it can be online, it will be online. In accordance with the principle of "who sponsors who is responsible and who approves who is responsible", the requirements for epidemic prevention and control will be strictly implemented.

　　12. If the wedding is postponed, the funeral is simple, and the banquet is not held, to reduce the gathering time and control the number of people, the participants must strictly implement the "four-piece set".

　　13. Advocate the general public in the city not to leave Shen unless it is necessary. Those who really need to leave Shen must hold a negative nucleic acid test certificate within 48 hours and travel with the green code of "Liaoshitong Health Code".

　　District and county (city) epidemic prevention and control headquarters can formulate specific prevention and control programs in combination with the actual situation.

　　Second, strict normalization of epidemic prevention and control key measures

　　1. Strictly implement the "active filing". Before arriving in Shenyang, all foreign (returning) Shen personnel should download the "Grand Event Link" App, search for "Grand Event Link" by WeChat applet or scan the QR code of "Self-reported by Shen personnel", complete self-reported to local communities (villages) and units one day in advance, report to local communities (villages) and units as soon as they arrive in Shenyang, and implement various control measures according to requirements. The community (village) should do a good job in service to ensure the living needs of residents.

　　2. Strictly "check on landing". At airports, railway stations, passenger stations, highways and other entry channels, they will be reported for inspection, and "landing" nucleic acid testing will be conducted free of charge.

　　3. Strictly implement classified control measures. Strictly implement classified control measures such as centralized isolation, home isolation, home health monitoring and nucleic acid detection for those who come (return) to Shenyang in high, medium and low risk areas outside the territory.

　　4. In high-risk areas, people who really need to go out for medical treatment should be coordinated and arranged by communities (villages) and streets (towns), and a special car should be used for personal protection and closed-loop management.

　　5. In the medium-risk area, "people don’t leave the area and take things at the wrong peak". For those who really need to go out for medical treatment, the community (village) will issue a certificate and make a good audit and registration.

　　6. In low-risk areas, "personal protection, avoiding gathering" shall be implemented, and during the period, going out as little as possible, not gathering, not getting together, and doing personal protection when going out; Strictly implement measures such as booking, peak shifting, current limiting, temperature measurement, registration and wearing masks when entering indoor public places.

　　7. All kinds of units, institutions, public places, residential areas, "nine small places" and other comprehensive applications of "place code" to achieve global coverage, everything must be swept; Strictly check the "four-piece set" for all personnel entering.

　　8. All pharmacies should register the personnel who buy antipyretic, antitussive, antiviral, antibiotic, cold and other drugs with their real names.

　　Third, strictly compact the "four-party responsibility"

　　We will further tighten the "four-party responsibility" of the territories, departments, units and individuals, and strictly implement various prevention and control measures such as "four-piece inspection", reporting of personnel coming (returning) to Shenyang, inspection on landing, site code, employee monitoring and daily ventilation and disinfection in accordance with the requirements of epidemic prevention and control. Places, units and individuals that fail to do a good job in epidemic prevention and control and fail to implement the "four-party responsibility" according to regulations shall be dealt with severely according to law.

　　Citizens and friends, in the face of severe and complicated epidemic situation, let’s tighten the string of epidemic prevention and control together, always do personal protection, adhere to good living habits such as wearing masks, washing hands frequently, often ventilating, using public chopsticks, consciously abide by various epidemic prevention regulations, protect ourselves and defend the city, and love and protect the city as home!

　　This circular shall come into force as of the date of promulgation, and shall be adjusted as the epidemic situation changes.

　　Shoulder-to-shoulder queue, the booming catering industry … … With the optimization and adjustment of epidemic prevention and control policies, offline consumption scenes such as restaurants and restaurants have been restored in an orderly manner, driving related consumption to pick up. According to data released by the National Bureau of Statistics recently, from January to February 2023, the national catering revenue increased by 9.2% year-on-year.

　　Food and beverage consumption demand has been greatly released.

　　Recently, "one table is hard to find" has become a common feeling for many consumers to eat. At the Chaoshan beef shop in Beijing Road, Guangzhou, the "Chaofa" has a long queue, and there are dozens of tables waiting at 6 pm. By the weekend, the average daily number of this store is nearly 1,000 tables. The waiter trotted to serve food and shouted, "It seems that the guests can’t finish receiving it recently."

　　Passenger flow recovery promotes turnover growth. From January to February, 2023, the brands owned by Beijing Huatian increased by about 12% year-on-year. Among them, Tongheju Restaurant and Xinchuan Noodle Restaurant increased by more than 20% year-on-year. In particular, the sales of Tongheju Restaurant and Eryouju in February have exceeded 2019 and returned to normal levels.

　　In order to help the catering industry recover, from January to February, Beijing, Shenzhen and Hangzhou issued special coupons for catering, with obvious results. According to the data of Meituan, after Hangzhou, Ningbo, Shaoxing, Shenzhen, Zhuhai, Dongguan and other cities issued coupons, the year-on-year growth rate of food consumption in restaurants reached double digits. In addition to issuing consumer vouchers, many local governments have also introduced policies to further optimize the business environment, including supporting outbound operations and launching "catering loan" financial products.

　　The "small" of catering reflects the "big" of development. According to the analysis of China Cuisine Association, from January to February, 2023, the growth rate of national catering revenue and catering revenue of units above designated size increased by 0.3 percentage points and 0.1 percentage points respectively compared with the same period of last year. From January to February this year, the national catering revenue accounted for 10.9% of the total retail sales of consumer goods, which was 5.7 percentage points higher than the total retail sales of consumer goods.

　　The relevant person in charge of the China Cuisine Association believes that from January to February, driven by the Spring Festival holiday and the policy of helping enterprises, the demand for catering consumption was greatly released, and the catering market rebounded significantly, which made a good start for the development of the whole year and played a "catalyst" role in boosting consumer confidence in 2023.

　　Customers dine in the Wuyi Hotel in Xi ‘an. Xinhua News Agency reporter Li Jiaxu photo

　　New kinetic energy "combustion-supporting" catering market

　　Potted vegetables and quick-frozen vegetables … … Guangzhou Restaurant accelerated the research and development of new prefabricated dishes and product upgrading, and the revenue of quick-frozen food was once the company’s second largest source of income. The White Paper on the Development of Prefabricated Vegetable Industry in China in 2022 shows that the scale of prefabricated vegetable market in China will reach 419.6 billion yuan in 2022, up by 21.3% year-on-year, and it is estimated that the market scale will exceed one trillion yuan in 2026.

　　Cheng Gang, secretary-general of Guangdong Food and Beverage Service Association, believes that due to the epidemic, people’s consumption behaviors and habits have changed, and many catering entities are "looking for opportunities in danger". Some actively adjust their business methods, including innovating catering products such as prefabricated vegetables, strengthening industrial cross-border integration, overlapping emerging consumption elements, expanding business space, optimizing brand experience and cognition, and finally enhancing consumer trust to activate the market, so as to achieve more stable, sustainable and virtuous development.

　　Including live broadcast, short video, digital channels and social sharing functions to help stimulate consumer demand, attract more passengers and stimulate catering consumption. "We enhance the brand’s popularity by planning videos such as the Fat Story Collection and the food recommendation official shop." Chai Biao, chairman of Feifei Shrimp Village, said that 70% to 80% of the passenger flow in some stores comes from the network platform.

　　More time-honored brands try cross-border innovation, combining eating and drinking with tourism, performance, entertainment, shopping and other formats, and enriching the consumption experience with diverse new scenes. In Shaanxi, there are more and more tourists in Yi Sushe Cultural District of Xi ‘an, which integrates Shaanxi opera performance, time-honored food and new retail of the country. Xi’ an restaurant head office lets customers immerse themselves in the local food culture through the Shaanxi cuisine culture experience museum; Time-honored enterprises turned into "convenience community canteens" and opened a new model of community chain.

　　Jin Wenping, secretary of the Party Committee and chairman of Xi ‘an Catering Co., Ltd. said that the opening of a new chapter of diversified development by time-honored brands is the epitome of the market-oriented reform and exploration of the catering industry with consumer demand as a breakthrough, which is conducive to promoting the development of the industry and enhancing the social and economic benefits of the brand.

　　New measures to stabilize industry confidence

　　"Give priority to restoring and expanding consumption", "Enhance consumption capacity, improve consumption conditions and innovate consumption scenarios" … … We will implement the requirements of the Central Economic Work Conference, and all localities will further clarify policies and stabilize expectations.

　　The policy of benefiting enterprises and benefiting the people continued to increase, boosting food and beverage consumption. For example, Beijing holds a variety of catering activities to promote consumption; Guangzhou has successively introduced catering support policies, with a maximum reward of 1 million yuan for transformed and upgraded catering enterprises and 2 million yuan for enterprises with increased turnover; Wenzhou has introduced ten measures to boost the confidence of catering industry development around reducing the institutional cost of catering industry access.

　　The main body of the catering industry is more confident and the investment layout is accelerated. Not long ago, at the China (Guangzhou) Catering Industry Development Conference and Investment and Financing Cooperation and Exchange Exhibition, hundreds of catering enterprises proposed nearly 1,000 brand catering investment projects, including Guangdong cuisine, Hunan cuisine, Sichuan cuisine, Shandong cuisine and other major domestic cuisines, as well as Japanese cuisine, Southeast Asian cuisine, Central Asian cuisine and other international flavors, with an investment of more than 3 billion yuan.

　　Zhang Yi, the person in charge of Ai Media Consulting, a third-party research institution, said that the expansion of the catering industry shows that confidence has gradually recovered, diversified and tends to middle and high-end projects. The catering industry pursues higher quality brand development and provides better services for consumers.

　　"From banquets, dinners, business receptions, prepared dishes and other aspects, we can see the signal of rapid recovery of the catering industry. New models, new channels and new technologies are constantly emerging, promoting the development of the catering industry to multiple formats and quality. " Chen Jianqi, vice president of Shaanxi Cooking and Catering Industry Association, said that it is also necessary to pay attention to the low threshold, intensified industry competition, low overall profit rate and increasing cost of raw materials and services. Therefore, it is necessary to make further efforts in specialization and industrialization to improve competitiveness.

　　Insiders said that in order to accelerate the comprehensive and steady recovery of the catering industry, it is necessary to continuously improve policy support and guidance, introduce policies to help and promote consumption that are more in line with enterprise needs and market expectations, guide the cultivation of leading enterprises and leading talents, and rationalize the industrial layout. At the same time, it is necessary to promote development and anti-waste, to innovate products and to keep the bottom line of food safety. (Reporter Ding Le, Ning Ji, Cai Xinyi, Li Jiaxu)

　　Beijing, June 15th (Reporter Qiu Yu) The last legal holiday in the first half of this year — — Dragon Boat Festival is coming!

　　The college entrance examination is over, the graduation season is here, and the World Cup has begun. This small holiday, is it necessary to let go of yourself?

　　If you plan to travel, you can collect this guide, which will make you have fun and worry-free, and avoid crowds.

　　First of all, people who travel in go on road trip or by bus should pay attention:

　　Dragon boat festival holiday,High speed is not free..

　　Say it again,Normal highway toll collection during Dragon Boat Festival.

　　Trend of congestion during the national high-speed Dragon Boat Festival. Source: 2018 Dragon Boat Festival National Highway Network Travel Forecast Report issued by the Ministry of Communications in conjunction with other institutions.

　　If you want to avoid the headache traffic jam, pay attention to the following peak hours:

　　Ministry of communications estimatesJune 16th is the peak of travel.,9: 00 am to 12: 00 am on the same day is the peak travel time; Especially from 10: 00 to 11: 00, the congestion degree is the highest.

　　June 18th is the peak of return trip.,On the same day, 15: 00 -21: 00 pm was the peak time of return trip, and the peak appeared at 16: 00 -17: 00.

　　Which highway sections are prone to congestion?

　　It is estimated that the highways with high traffic flow include: Hebei section of Jingcheng Expressway, Beijing section and Hebei section of Daguang Expressway, Guangdong section of Guanfo Expressway, Hunan section of Beijing-Hong Kong-Macao Expressway, Jiangsu section, Shanghai section and Zhejiang section of Shenhai Expressway.

　　The expressway around the city with high traffic volume includes: Guangzhou Ring Road, Chengdu Ring Road, Shanghai Ring Road and Hangzhou Ring Road Expressway.

　　Provincial congestion during the Dragon Boat Festival. Source: 2018 Dragon Boat Festival National Highway Network Travel Forecast Report issued by the Ministry of Communications in conjunction with other institutions.

　　The Ministry of Communications predicts that,The high-incidence areas of expressway network in provinces are mainly concentrated in Guangdong, Beijing, Jiangsu, Zhejiang, Hebei and other areas with strong traffic demand or concentrated self-driving tourism.

　　Some people choose to travel by high-speed rail. Have you grabbed the tickets for the following popular routes?

　　Meituan Travel Big Data shows that during the Dragon Boat Festival, the demand for high-speed rail travel is mostly in the province, and the top three popular routes are Guangzhou-Shenzhen, Chengdu-Chongqing and Hefei-Lu ‘an.

　　Jingzhou-Wuhan, Beijing-Tianjin, Chengdu-Xi ‘an, Chengdu-Mianyang, Shenzhen-Xiamen, Wuhan-Yichang and Wuhan-Xiangyang high-speed rail lines are also very popular.

　　Small partners who want to fly can also find cheap air tickets in relatively "unpopular" places.

　　Ctrip data shows thatFly to Fuzhou, Kunming, Guiyang, Quanzhou and overseas destinations such as Sydney and Singapore, and the ticket price is nearly half cheaper than last year’s Dragon Boat Festival.Come and pick up the leak!

　　On the contrary, Beijing, Chengdu and Xi ‘an have become the top three popular destinations in China. It is difficult to see tickets with a discount of less than 20% during hot hours, and some flights only have full-price tickets in economy class.

　　By the way, this year’s Dragon Boat Festival is different from the past, because there is an important event — — World Cup.

　　According to Ctrip data, during the small holiday,The destination with the most obvious price increase is Russia, the host of the 2018 World Cup, with the increase of more than 30% compared with the group and free travel routes.

　　However, the enthusiasm of China tourists has not diminished. During the World Cup, the number of Ctrip Russian tour groups has increased by 60%.

　　In addition, the weather is also a key factor in the journey.

　　According to the forecast of the Central Meteorological Observatory,During the Dragon Boat Festival holiday, there will be a strong rainfall process in the eastern part of southwest China, the lower reaches of Hanshui River and the north-central part of the south of the Yangtze River. There will be heavy rain in some areas and heavy rain in the local area, accompanied by strong convective weather such as short-term thunderstorms or hail.

　　If you want to travel to these places, you’d better prepare rain gear in advance.

　　Refer to the above information, make a good travel plan, and wish you a beautiful Dragon Boat Festival holiday.

　　Finally, I will tell you quietly that it will be more than three months before the next legal holiday is over after this small holiday. So, cherish the holiday and have fun.

Yang Jianfei: Computational Medicine Promotes Accurate Clinical Trials.

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Yang Jianfei, Chief Scientific Officer of Zheyuan Technology

Computational medicine needs to be composed of interdisciplinary teams and platforms. By integrating supercomputing system, AI platform, molecular and clinical data, massive literature and biological information, it can realize effective analysis and calculation of drug development and assist decision-making.

Taking an anti-tumor drug in our pipeline as an example, we read all the literatures of the target disease by using the "TWIRLS stick" of the computational medicine platform, first we have all the scientific knowledge known on the earth at present, and then we analyze the digital twins of patients in the patient database in a data-driven way to obtain the disease mechanism, specific targets and "portraits" of patients.

As we all know, the tumor is heterogeneous in time and space, and the immune system around the tumor is particularly complex. Therefore, only by having an accurate "portrait" of the patient’s tumor and accompanying diagnosis can we enter the stage of accurate clinical trials.

Through the computational medical platform, we established the response mechanism model of CDK4/6 inhibitor, and the effectiveness of this model was verified by the data of TCGA and Chinese patients. Then we put this drug currently used to treat breast cancer on the computational medical platform to study whether it has other applicable diseases. It was found that the model score of chordoma was very high, so we established cooperation with shanghai changzheng hospital and saw that some patients achieved partial remission in the third week after taking the drug. Although this drug has not yet entered the clinical trial stage, as long as it is carried out in accordance with the norms of computational medicine platform, we are confident to achieve truly accurate clinical trials.

Peng Ao: Behind the clinical success rate from 2% to 21%

Peng Ao, Project Management Team Leader of Pfizer China Product Line

The efficiency of Pfizer’s new drug research and development has increased from 2% to 21%. I think we can sum up three experiences. First, accurate positioning, clear their own specific advantages in the field of biology. Pfizer currently focuses on internal medicine, immunity and inflammation, oncology drugs and vaccines. Second, choose the drug mode. At present, more complex and novel molecular entities account for more and more in our pipelines. Thirdly, the decision-making adheres to two principles. First, quantitative POM analysis is carried out in the first and second phase of the experiment, which can help the success rate of the second phase reach 40%; The second is to plan again. If the first direction of clinical research and development fails, then we will transform it and try again in another direction. If there is a very clear biological basis, our success rate can reach 31%.

Ertuglifozin is a SGLT-2 hypoglycemic agent, and a large number of technologies and methods related to computational medicine are used in its research and development, including systematic pharmacological model and Emax Model. Using this model, the highest hypoglycemic effect of the drug can reach 77%. Meta-analysis shows that the drug has the highest hypoglycemic level among similar products. This is a typical case of using model or computational medicine to guide drug research and development.

The US Food and Drug Administration has begun to build a framework for digital health tools. I believe that after the introduction of the framework, the guiding principles of the corresponding rules will also be introduced, which will guide the application of some new drug research and development more specifically and deeply.

Tang Yu: The insights generated by computational medicine need to be verified clinically.

Tang Yu, Executive Director of the Office of Drug Clinical Trial Research Center, Cancer Hospital, China Academy of Medical Sciences

Computational medicine has produced a large number of insights by analyzing massive data, but how to prove that these insights are authentic and can be used in clinical practice through clinical trials?

The first case is to verify the specific answer given by computational medicine to a specific problem, such as verifying whether the first innovative drug under the guidance of AI can treat pancreatic cancer. The second is based on massive data to verify whether the treatment mode formulated by AI for individual patients or groups is better.

In the course of such an experiment, we need to consider several issues:

First, the consistency of the AI model. When we want to prove that an algorithm or an AI-based paradigm can guide medical care, we must ensure the consistency of the paradigm and not make it change irregularly.　

Second, it is necessary to consider whether there is an accessible clinical treatment for a class of patients with more concentrated biological characteristics found by AI model. If there is no targeted treatment, although this model can guide the prognosis of patients, it is difficult to change the existing treatment methods.

Finally, establish a model that can not only explain the results, but also explain the mechanism, so as to better combine human wisdom with the wisdom of computer based on data integration.

At present, we are carrying out an umbrella research design, focusing on soft tissue sarcoma. Although the overall incidence of the disease is not high, there are nearly 100 subtypes. Our anti-vascular targeted drugs have shown excellent effects in individual subtypes, but the overall effect is still not ideal. Therefore, we hope to use Turing Darwin’s laboratory’s in-depth analysis of the whole sarcoma mechanism and digital twin technology to find drugs with ideal curative effect and high accessibility.

Niu gang: the big disease model changes the new paradigm of drug research and development

Niu Gang, Director of Turing Darwin Laboratory

In today’s medical field, we are committed to collecting and utilizing all kinds of disease-related data, looking for clues of logical unity for diseases, and establishing complex and real mechanism portraits. But the key lies in how to understand the so-called mechanism and who is the subject of the complex mechanism?

We have built and trained a brand-new AI method-"Genome Shotgun Damage Assessment Process" (DAGG). By inputting the sequence information of human germ line or tumor genome, AI can translate the sequence gobbledygook that human can’t understand into understandable changes in cell function.

According to the information of genome variation, clinicians can use DAGG to judge whether HER2 gene is amplified in tumor cells of breast cancer patients, so as to further clarify the pathological types of patients and provide clearer and more accurate judgments for patients’ diagnosis and treatment.

With the DAGG method, we can also transform the real patient data into the digital twins of the patient and his disease. With the large-scale accumulation of patients’ digital twins in virtual environment, we conducted a large-scale virtual clinical trial for PD-1/PD-L1 monoclonal antibodies. The results showed that the efficacy of most immunodrugs with indications was not ideal.

Therefore, the virtual clinical trial based on digital twins can replace the original clinical trial results that cost tens of billions of dollars. Based on the curative effect data of a small sample of individual indications, the potential indications of other tumor diseases can be inferred. At the same time, according to the biological mechanism directly suggested by the model, the combination scheme and even new molecules can be rationally designed, which saves many clinical development steps and costs and ensures greater benefits for patients.

Shi Rong: Computational Medicine Helps Accurate Diagnosis and Treatment of Breast Cancer

Shi Rong, Secretary General of Cancer Prevention and Treatment Committee of Wu Jieping Medical Foundation.

Breast cancer is the largest cancer in the world. HER2 is a definite prognostic indicator and a predictive indicator of drug treatment effect for breast cancer, but the tumor heterogeneity of HER2 expression is obvious, and the detection method of HER2 can not meet the demand of anti-HER2 treatment. Therefore, studying the etiology of the germ line carried in the germ line genome is not only helpful to deeply understand the pathogenesis of breast cancer, but also helpful to develop new methods and provide prospective judgment for subsequent treatment.

Recently, the artificial intelligence algorithm DAGG independently developed by the computational medicine team revealed the pathogenesis of breast cancer. It is found that the signal pathway function spectrum (APSP) can be obtained by using the DAGG model based on the germline fingerprint rare coding variation data. According to the difference in the distribution of APSP between patients and people with low etiology, a prediction model can be effectively constructed to evaluate the etiological risk of female individuals, and the HER2-positive and HER2-negative breast cancer patients can be effectively distinguished.

The clinical transformation path of breast cancer based on APSP is divided into three steps. The first step is to guide the clinical treatment plan based on the pathological classification of breast cancer by APSP. The second step, based on APSP, is the extremely early diagnosis of women with breast nodules and breast cancer with familial breast cancer genetic history, so as to reduce the proportion of breast cancer patients who enter advanced and advanced stages at the first diagnosis. The third step, breast cancer risk assessment of healthy population based on APSP, fills the gap of the lack of effective primary prevention measures for breast cancer in the world.

Jiang Min: Virtual clinical trial is a new paradigm in the future.

Jiang Min, Director of the Office of National Drug Clinical Trial Institution of Peking University Cancer Hospital

From a global perspective, there have been exploratory studies on virtual clinical trials, but retrospective cases are the main ones. Regarding whether we can carry out prospective virtual trial design and generate higher-level digital evidence to verify the computer simulation model, so as to better guide clinical research, Peking University Cancer Hospital and the computational medicine team collided from the perspectives of technology and experimental requirements, forming a real landing research.

The two sides jointly carried out a parallel virtual clinical research project by using the digital twin model of patients in computational medicine. The purpose of the research is to explore the relationship between the pathogenesis of tumor and the mechanism of anti-tumor drugs. Through the virtual clinical trial, the curative effect of anti-tumor drugs is predicted, and the characteristics and differences of patients are analyzed, so as to optimize the design of clinical trials. This study compares head-to-head with a real clinical study of registered new drugs to verify the consistency between the predicted results of virtual clinical research and the curative effects of real-world clinical trials.

Virtual clinical trial is a new paradigm in the future. With the support of computational medicine technology, the future clinical trial model may be transformed into more accurate clinical trial design, which will bring a more holistic drug research and development idea, which will bring revolutionary changes to the success rate and effectiveness of clinical trials.

Roundtable Forum I: Cognition and Evaluation of Non-consensus and Subversive Technology

Moderator: Li Lei, Associate Research Fellow of Frontier Science and Education Bureau of China Academy of Sciences.

Roundtable forum site.

Lv Benfu (Professor, School of Economics and Management, Chinese Academy of Sciences)The so-called breakthrough innovation mainly depends on three points. First, whether a brand-new track has been developed; Secondly, on the original track, whether its performance-to-value ratio conforms to the law of ten times speed; Third, whether it belongs to the pattern innovation from 0 to 1 depends on the support of industrial policies.

Gu Chengming (Head of Sanofi Greater China Medical Department)The non-consensus stage is the primary stage. As long as it is accepted by the industry, it is considered as consensus, or it is available, which can solve some problems. However, in the field of drug research and development, if you want to be a First-in-Class, it must be a non-consensus. If you become a consensus, it will be Me too.

Zhang Chunming (Vice President of the Western Research Institute of Computing Technology, Zhongke)From a practical point of view, today’s world structure does not support small steps forward, and we must give full play to the ability of large-scale team operations. In terms of innovation, it is indeed possible for computational medicine to open up a brand-new track, so any government department should carefully evaluate it.

Weng Huajian (deputy head of Changning District, Shanghai)In 2021, I first learned about computational medicine. At that time, we envisaged to set up a life science innovation center between Suzhou and Shanghai, specializing in high-end research and development, focusing on computer +Inside and AI+, so as to give full play to the accumulation of digital economy in Changning, Shanghai in the past 20 years, especially the accumulation advantages of talents and innovation ecology. Therefore, from the perspective of the government, we are full of expectations for disruptive innovation technology in computational medicine.

Roundtable Forum II: Investment Logic from the Perspective of Computational Medicine

Moderator: translated by Hu Ming, partner of Mingde Capital.

Roundtable forum site.

Tian Feng (Minister of Industry Service Department of Shanghai Biomedical Industry Promotion Center)The most noteworthy point of the whole AI+ pharmaceutical industry is to change from logical successful practice to probabilistic successful practice, and finally return to logical successful practice. From the perspective of AI+ diseases, developing virtual clinical trials, I think it can effectively reduce the cost of clinical development and improve the success rate in the future.

Jing Xutian (Managing Director of Wuyuan Capital): AI technology has brought some new algorithms and breakthroughs in computing power. In the past, many AI pharmaceutical companies paid more attention to the field of small molecules with the most data and the most mature data, but today we see that more and more algorithms are actually very suitable for doing some new modal drug discovery.

Zeng Yingzhe (Partner of Linear Capital)Before AI technology, we usually build low-dimensional models to solve high-dimensional problems, but the emergence of AI can solve these high-dimensional problems. With more and more data and more powerful computing power, the prospect of AI pharmaceutical is very broad. At present, we are observing what progress the big language model will bring to AI pharmaceutical. It is exciting that some new progress has been made in the field of molecular characterization algorithms.

Ma Rui (partner of Fengrui Capital)We always overestimate the progress of computational medicine in five years, but underestimate the progress it can bring in ten years. I think that in the next three years, macromolecular protein drugs will basically be subverted by AI, just like AlphaFold in 2021 completely solved the problem of structural prediction of single domain proteins. (Photo courtesy of the organizer)

A few years ago, there was a movie called Shopaholic, which told the story of several people who were addicted to shopping. When they saw their favorite items, they couldn’t stop, even if they owed huge credit card debts, they had to take them home. Such people are called shopaholic in English. By analogy, then the "chatter" we are talking about today is talkaholic.

Talkaholic is a person who takes great pleasure in talking. A talkaholic has trouble keeping quiet and listening when other people are around.

Talkaholic refers to someone who likes talking and enjoys it, which is what we call "chattering" Generally, when others are present, it is difficult to talk without listening to others.

Similar words like workaholic and shopaholic are all ended with the same suffix -aholic, which means of an obsessive interest in something.

Both Workaholic and shopaholic, like talkaholic, have the suffix -aholic, which means they are extremely interested in or addicted to something.

For example:

Jane was a talkaholic who gave everyone her opinion whether they asked for it or not.

Jane is a chatty talker. She always gives her opinion whether others want to listen or not.

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"petrify" TV stoned in front of the TV.

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(Edited by China Daily English Dianjin Helen)

Click to see more English idioms and new words.

　　General Secretary of the Supreme Leader pointed out at the National Ecological Environmental Protection Conference: "Deepen the application of digital technologies such as artificial intelligence, build a beautiful digital governance system in China, and build a green and intelligent digital ecological civilization." At present, the integration and mutual promotion of digitalization and greening has become an important theme of global development. To promote the intelligent management of ecological environment and the construction of digital ecological civilization with green wisdom, we must adhere to the guidance of Socialism with Chinese characteristics Thought of the Supreme Leader in the new era, comprehensively implement the ecological civilization thought of the Supreme Leader, promote the comprehensive green transformation of economic and social development with digitalization, and provide strong support for the modernization of harmonious coexistence between man and nature.

　　The integration of digitalization and greening has become an important trend in the construction of ecological civilization.

　　Ecological civilization construction covers a wide range and is comprehensive, involving many aspects such as value concept, goal orientation, production and consumption mode, etc. It is a complex systematic project. Promoting the construction of digital ecological civilization can effectively enhance the systematicness and synergy of ecological civilization construction, and promote the formation of scientific and efficient methods and paths to solve ecological environment problems and expand ecological environment governance.

　　As a way of ecological environment governance, digital ecological civilization construction organically embeds big data, 5G, artificial intelligence and other digital technologies into ecological civilization construction, and continuously improves the scientific, refined and intelligent level of ecological civilization construction in the deep integration of digitalization and greening. The key to building digital ecological civilization lies in coordinating the relationship between digitalization and greening, and promoting their mutual promotion and coordinated development. Promoting digital construction, using artificial intelligence and other technologies to discover the laws behind the data, and fully releasing the superposition, aggregation and multiplication effects of digital technology in improving the efficiency, technological improvement and means optimization of ecological environment governance can provide an important engine for ecological environment governance and help to achieve efficient and sustainable ecological environment governance effects. Promoting green development is the proper meaning of building digital ecological civilization. By optimizing the spatial layout of the country, improving the utilization efficiency of resources and energy, strengthening environmental protection and ecological restoration, focusing on solving problems such as environmental pollution and ecological damage in the development process, matching resources, production, consumption and other factors is conducive to the simultaneous advancement of high-quality development and high-level protection.

　　Since the 18th National Congress of the Communist Party of China, under the guidance of the Supreme Leader’s New Era Socialism with Chinese characteristics Thought, especially the Supreme Leader’s Ecological Civilization Thought, China’s digital ecological civilization construction has made great progress, and the level of intelligent management of ecological environment has been significantly improved. In February this year, the CPC Central Committee and the State Council issued the Overall Layout Plan for the Construction of Digital China, which made "positive progress in the construction of digital ecological civilization" as an important goal for the construction of digital China in 2025, and put forward new requirements for the new generation of digital technology to help ecological governance. In the process of promoting the deep integration of digitalization and greening, China’s energy consumption in the whole chain has been significantly reduced, production efficiency and energy efficiency have been continuously improved, and the ecological benefits and economic and social benefits of green mountains have been continuously brought into play. At the same time, we should also realize that the construction of digital ecological civilization in China is still in its infancy, and there are still some problems to be solved in the construction of digital infrastructure, the construction of data standards and norms, the transformation and application of scientific and technological achievements, and the cultivation of digital ecological civilization talents. We should pay more attention to the use of digital technology to innovate the way of ecological civilization construction, constantly promote the deep integration of digitalization and greening, lead greening with digitalization, drive digitalization with greening, focus on strengthening the collection, adaptation, reconstruction and sharing of ecological environment big data, fully release the potential and vitality of ecological environment governance through digital ecological environment technological innovation, and provide strong kinetic energy for building a beautiful China.

　　Provide strong kinetic energy for the modernization of harmonious coexistence between man and nature.

　　The General Secretary of the Supreme Leader stressed: "We must plan development from the height of harmonious coexistence between man and nature, constantly shape new kinetic energy and advantages of development through high-level environmental protection, and strive to build a green and low-carbon circular economy system, effectively reduce the resource and environmental costs of development, and continuously enhance the potential and stamina of development." Building a green and intelligent digital ecological civilization provides strong technical support for accurate identification, real-time tracking of environmental data, timely judgment and systematic solution of ecological problems, and provides strong kinetic energy for promoting a comprehensive green transformation of economic and social development and building a harmonious coexistence between man and nature.

　　Effectively improve the level of intelligent governance of the ecological environment. Building a digital ecological civilization, integrating ecological environment data into digital technologies such as artificial intelligence, and constantly strengthening machine learning and training will not only help to analyze the historical evolution process of ecological environment more scientifically, but also provide important decision-making reference for timely judgment and systematic solution of ecological environment problems in pollution warning, duration prediction and emission reduction effect prediction, and promote the change of decision-making process from "empirical judgment" to "data analysis", making ecological environment governance more "smart" For example, in the Great Protection of the Yangtze River, the relevant departments have established a "data collection and management —" by building a monitoring network of the whole basin’s ecological environment from Qinghai to Shanghai, collecting and sorting out massive ecological environment data in the Yangtze River basin, developing and integrating water quality diagnosis, forecasting and early warning, pollution traceability, scenario simulation and other functions. Data Mining and Simulation — Virtual visualization — Analysis of pollution traceability — The digital management business system of water environment based on intelligent decision-making provides an important technical guarantee for realizing "one river with clear water flowing eastward".

　　Promote the transformation of ecological environment governance to synergy. In the past, due to the insufficient sharing of ecological environment data and information among regions, departments and units, the ecological environment governance has been fragmented to some extent, and the problem of "repeated governance and repeated governance" in some local ecological environment governance is more prominent. Building a digital ecological civilization and building a "network" of ecological environment data will help to break down data barriers, realize data interconnection, and consolidate the data foundation for the transformation of ecological environment governance paradigm from fragmentation and fragmentation to synergy and integrity. For example, in the response to heavily polluted weather, we should follow the general policy of holistic and whole-process collaborative governance, promote the sharing of basic data among relevant government departments, different scientific research institutions and different disciplines, carry out collaborative research on key areas and key issues, and scientifically put forward the timetable and roadmap for continuous improvement of air quality, so as to provide support for the realization of "blue sky, white clouds and twinkling stars".

　　Accelerate the pace of green and low carbon transformation. Digital technology, represented by a new generation of artificial intelligence, is accelerating the evolution of global scientific and technological revolution and industrial transformation, and promoting the reform of global governance system. Digitalization empowers the construction of ecological civilization and has the efficiency of "1+1>2". Intelligent manufacturing technology strengthens the data analysis ability of manufacturing enterprises in process, manufacturing, logistics and other aspects, and reduces the pollutant emission and carbon emission of product manufacturing; Smart energy system explores the data value of energy production, transmission, distribution, storage and other links, monitors and adjusts energy generation in real time, and improves the utilization efficiency of renewable energy; By establishing a carbon inclusive platform for green living, smart cities will count individual emission reductions into individual carbon assets and turn intangible green behaviors into tangible green values. To promote high-quality economic and social development, we need to keep up with the development trend of world science and technology, embrace digital technology, further improve the endogenous driving force of green and low-carbon transformation of production and lifestyle, and make economic and social development have higher green content, lower carbon content and more gold content.

　　Deepen the application of digital technology in the field of ecological environment

　　The construction of digital ecological civilization can focus on platform construction, data mining, digital intelligence integration, policy guarantee and other aspects to form a "network" and a "map", research and develop data value mining algorithms, promote the deep application of digital technology in the field of ecological environment, and give full play to the basic and leading role of digital ecological environment technology in the construction of beautiful China.

　　Improve the stereoscopic intelligence perception of the sky "a net". The collection and transmission of information is the key link in the construction of digital ecological civilization. At present, it is necessary to do a good job in the top-level design of digital ecological civilization infrastructure construction, build a three-dimensional multi-source monitoring and sensing network system for ecological environment, strengthen the application of big data acquisition technologies such as satellite remote sensing, aerial photography of unmanned aerial vehicles, automatic ground monitoring stations, underwater robots and the Internet of Things, continuously expand the accuracy and space-time breadth of monitoring, and build a multi-means comprehensive and fast-responding monitoring network covering various environmental elements of the atmosphere, water, soil, ecology and ocean to realize global monitoring and sensing of ecological environment elements. Strengthen the construction of digital infrastructure that adapts to intelligent decision-making and green development, and build an "information high-speed rail" for the safe and rapid circulation of ecological environment data, laying a solid foundation for the rapid and accurate use of data.

　　Form a "one map" of national ecological environment data. Data is the key to the construction of digital ecological civilization, but fragmented data can’t play its value. To speed up the collection of eco-environmental data, on the one hand, it is necessary to promote the collection and exchange of eco-environmental data, and realize the cross-level communication and cross-departmental sharing of eco-environmental monitoring and monitoring data and their related information. Comprehensively collect environmental data such as environmental quality, pollution sources, sewage outlets, and ecological environment functional zoning, and promote coordinated management, precise management, and overall improvement of regional ecological environment with resource sharing, complementary advantages, and mutual benefit, so that the data can "run" out of great value. At the same time, strengthen data connectivity with natural resources, water conservancy, meteorology, energy, agriculture, forestry, transportation and other fields, and promote multi-source data integration. On the other hand, it is necessary to firmly grasp the standard, improve the standard system for the collection, integration, classification, sharing and application of eco-environmental data, and actively promote the formulation of digital international standards in the field of eco-environment, so as to contribute to building a green "Belt and Road" and building a global ecological civilization.

　　Develop a value mining algorithm for massive data. The model is the golden key to open the data treasure mine. It is necessary to make full use of digital technologies such as augmented reality and artificial intelligence, strengthen large-scale model simulation, form a more comprehensive and scientific understanding of the evolution of ecological environment and the causes of pollution, and provide multi-dimensional data analysis, early warning and forecasting, and traceability for scientific decision-making and precise governance. Using big data analysis, artificial intelligence, visualization and other technologies, we will strengthen the research and development of digital technologies such as intelligent perception and sharing, fusion and deduction, characterization and expression of environmental data, and inject wisdom genes into key areas such as ecological environment monitoring and early warning, integrated protection and system management of grass and sand in mountains, rivers, forests, fields and lakes, comprehensive prevention and control of multi-media environmental pollution, solid waste reduction and resource utilization, new pollutant control, and response to climate change, and continuously enrich the application scenarios of digital technologies in the field of ecological environmental protection.

　　Promote digital technology to be embedded in the whole process of environmental governance. The deep integration of digital technology and environmental governance has greatly improved the modernization level of ecological environmental governance. Give full play to the advantages of digital technology in breaking through the limitation of information time and space, smooth the interactive channels across regions, levels and departments, gather the strength and wisdom of the government, enterprises and the public, promote the formation of a networked and open multi-collaborative governance pattern, and integrate digital technology into the whole business and life-cycle management of ecological environment such as monitoring and evaluation, supervision and law enforcement, so as to improve the efficiency of environmental governance. Leading green development with digital transformation and optimization of ecological environment management, promoting the transformation and upgrading of industries such as steel, coal, electricity, chemicals and building materials, improving green total factor productivity, reducing energy and material consumption in the whole chain, and promoting the organic unity of economic benefits and ecological benefits.

　　Lay a good job in policies, talents and combination boxing. Constantly improve the policy system that is conducive to the deep integration of digital technology and ecological civilization construction, dismantle the barrier between the environmental governance side and the technology supply side, and create an innovative environment where major digital scientific and technological achievements in the ecological environment field are constantly emerging. Strengthen the research on relevant laws, regulations and policies, and strengthen the open sharing of data on the premise of ensuring data security. Cultivate and introduce compound cross-border talents with professional knowledge in digital technology and ecological environment, and form a three-dimensional and high-level echelon of digital technology talents in ecological environment. We will build a scientific research management system and mechanism conducive to the breakthrough of the core technology of digital ecological civilization, establish and improve a market-oriented diversified investment model, and increase support for digital strategic frontiers and applied basic research in the field of ecological environment.

　　(The author is Dean of china environmental science Research Institute)

1905 movie network news It’s another year of fashion week! On September 15th, local time, in London, England, David Beckham brought a handsome boy and a beautiful woman to his wife’s Victoria fashion brand launch conference. On the same day, Beckham made a handsome appearance in a gray suit; The three sons, Brooklyn Beckham, Romeo Beckham and cruz beckham, all chose casual clothes and sat side by side with their father.

Harper seven beckham, the "Seven Princesses" who has attracted much attention, is dressed in a floral dress with a high ball head, and is full of celebrities. From time to time, Qi Princess, who sits on her father’s lap, has a hot chat with anna wintour, the "devil wears Prada" beside her.

Pacific science and technology informationOn August 22nd, Apple’s marketing team did an excellent job in promoting the advantages of its products and chips, even if it meant misleading consumers into believing that they were actually investing in cutting-edge products. Previously, the market generally thought that the iPhone 14 Pro and iPhone 14 Pro Max were equipped with A16 bionic chips manufactured by TSMC in a 4-nanometer process. However, a person familiar with the matter overturned this view. He revealed that Apple internally marked this chip as a 5-nanometer chip, instead of the expected 4 nanometers.

The whistleblower further confirmed that A16 bionic chip was labeled as a 5-nanometer chip inside Apple. This may explain why Apple mentioned in the press release that the M2 Pro and M2 Max chips in the new 14-inch and 16-inch MacBook Pro models are mass-produced on the 5-nanometer process instead of the 4-nanometer process.

On the other hand, Apple’s next-generation A17 bionic chip is determined to adopt TSMC’s most advanced 3 nm process. Due to the transition from 5 nm to 3 nm, the performance leap between A16 and A17 will be huge. It is reported that in the previous benchmark test, compared with the previous generation, A17 bionic chip has improved as much as 31% in single-core and multi-core results.

It is worth noting that this latest news makes the upcoming iPhone 15 Pro and iPhone 15 Pro Max more attractive, because both phones will be equipped with A17 bionic chips. However, the relatively low-priced iPhone 15 and iPhone 15 Plus may use A16 bionic chip.

However, this has also triggered netizens’ speculation, whether A17 is just another product promoted by Apple’s comprehensive marketing promotion, or whether the customized chip is actually designed and mass-produced on a brand-new architecture. Some netizens claimed that TSMC’s 3-nanometer process may only reduce the 5-nanometer nodes, and the real 3-nanometer process should adopt N3E technology. So far, we are disappointed that A16 is not a 4nm component, but this is not surprising, because the company always follows this practice.

Cctv newsAccording to the WeChat WeChat official account news released by Sanya, on the morning of March 17, 2023, the video of "A tour guide in Sanya suspected that tourists scolded tourists because they didn’t shop" attracted the attention of the media and netizens. The Sanya Municipal Bureau of Tourism and Culture, Radio, Film and Television Sports, the Municipal Comprehensive Administrative Law Enforcement Bureau and other departments attached great importance to it and immediately organized an investigation.

After investigation, the tour group in the video was a four-day and three-night individual tour group received by Hainan Xinxianglian International Travel Service Co., Ltd. (registered at Room B207, Floor 2, Building B, Shengshenghuiyu, No.35 Nansha Road, Longhua District, Haikou City) on February 23, 2023. The tour guide was Yang Moumou (female), and his tour guide card was attached to Hainan Xinhuanyou International Travel Service Co., Ltd. (registered at Floor 4, Blue Sky Plaza, No.19 Heping Avenue, Heping South Street, Meilan District, Haikou City

At present, the Comprehensive Administrative Law Enforcement Bureau of Longhua District of Haikou City has ordered travel agencies to improve the service quality of employees and tour guides; The tour guides involved have made a Record of Investigation and Inquiry, which will be handled according to the law. Citizens and tourists can call the Sanya municipal government service hotline at 0898-12345 immediately if they find illegal business practices in the tourism market. In view of the illegal acts in the tourism market, the relevant departments of our city will severely investigate and deal with them and will never tolerate them.

Comprehensive improvement of tourism market and environment in Sanya City

Work leading group office

March 17, 2023

If you don’t go to sea, you are out.In recent years, e-commerce "going out to sea" has been frequent., major e-commerce platforms are also there.Constantly update the "gameplay" to meet the needs of merchants and cope with market changes.according toGeneral Administration of CustomsThe latest statistics released show that in the first half of the year, the import and export volume of cross-border e-commerce in China reached 1.22 trillion yuan, up 10.5% year-on-year, which was 4.4 percentage points higher than the overall growth rate of China’s foreign trade in the same period.

As a "happy hometown" for countless cross-border e-commerce sellers,1688 is also making efforts in cross-border e-commerce. On September 11th, 2024, at the press conference of "1688 Selection Center and 1688 Businessmen’s Festival" held in Taizhou, the person in charge of the 1688 Selection Center revealed that 1688 should rely on the offline selection center to make heavy investment in the industrial belt. At the same time, 1688 is aiming at the new outlet of cross-border e-commerce and laying out the whole link ecology of cross-border e-commerce.

Create the shortest link matching supply and demand

Nowadays, the supply of industrial belts is the focus of major platforms, and 1688 is no exception. At the press conference, the person in charge of the 1688 product selection center believes that the most advanced and shortest path to realize the digitalization of the industrial belt is to establish an online and offline integrated operation and service model. Therefore, the 1688 product selection center is jointly built by the government, chain owners, 1688 and the source manufacturers of industrial belts. Through the "four-in-one" online and offline operation mode, a business ecosystem of industrial belts with digital supply chains is jointly built, not just an offline entity.

The offline product selection center is set up, endorsed and guided by the government. The chain owner of the local supply chain is responsible for the daily operation, and the industrial belt factory is stationed to jointly aggregate the high-quality goods of the industrial belt, create a "front office and back warehouse" model, and provide comprehensive services integrating enterprise services and warehousing and logistics. Online, 1688 has also built a digital store in the product selection center, providing technical and digital capabilities, and relying on the advantages of 1688′ s entire network source, it has achieved omni-channel sales and efficient matching between supply and demand.

Image source: 1688

As of September 2024, 1688 has signed a cooperation agreement to build 12 product selection centers, of which 4 have been opened, and 6 are expected to open in September this year, mainly in Taizhou, Yiwu, Yongkang and Jiaxing in Zhejiang, Shenzhen, Guangzhou, Shantou and Jieyang in Guangdong, and Zhengzhou in Henan. In the next three years, 1688 will continue to deeply cultivate 177 key industrial belts in 40 cities based on the core production areas and sales areas.

"In fact, what we hope to bring to the source factory of the industrial belt is the most efficient and shortest path business model. The core positioning of the product selection center is’ visiting the industrial belt in one day’. Whether you are visiting the industrial belt or purchasing it, whether you are an online digital shopping center or an offline shopping center, you can see the ability and panorama of the industrial belt, making it easy to purchase in one stop. " The person in charge of 1688 selection said.

1688 has been deeply ploughing and reinvesting in the industrial belt. Now, in 1688, it is necessary to increase investment and put the core strategic projects into the industrial belt one after another. The 1688 member store will rely on the offline product selection center as the springboard and bridgehead, go out from 1688, and open stores from online to offline at the same time, and establish white-label supply chain supermarkets for Sam member supermarkets and costco (opening customers) under the marking line.

It is reported that the goal of developing member stores in 1688 is to build a "global member store driven by white brand supply chain", and to provide services to members online and offline. At present, the number of paid members of 1688 has reached nearly 10 million, exceeding the scale of paid members of Sam in China, and the number of members in the past year has increased by more than 400% year-on-year.

The supply of 1688 offline member stores will be relatively vertical, and different sources will be supplied according to different industrial belts. Next, 1688 will gradually combine the characteristic trend products of various industrial belts with offline product selection centers, so that every member of 1688 can buy the national characteristic white-brand products locally.

At the same time, 1688 YEATION will also rely on some product selection centers, unite with China’s major brand foundries and factories with strong R&D and manufacturing capabilities, and launch 1688 YEATION’s branded products, further giving play to the advantages of large-scale supply chain, so that 1688 members can enjoy more differentiated quality products.

Output "supply chain solutions" that can be integrated.

Product selection is the primary link of cross-border e-commerce. The person in charge of the 1688 product selection center revealed that the "Domestic YEATION" was launched in 1688. Now, in order to better help cross-border e-commerce sellers to select products, the "Cross-border YEATION" will be launched. According to the latest consumption trends of overseas consumers, products that meet the needs of cross-border e-commerce sellers will be screened out to provide guarantee for product quality and back-end services.

Image source: 1688

At present, 1688 focuses on just-needed categories of consumption, which, in summary, are eating, drinking, having fun, daily use and beauty trends. For example, Zhengzhou’s food, Shantou’s toys, Taizhou’s storage, Yiwu’s Ribai, Guangzhou’s beauty cosmetics, Shenzhen’s digital products, Jieyang’s household appliances, etc. are all core categories of the industrial belt and just-needed categories.

The person in charge of the 1688 product selection center said: "1688′ s cross-border e-commerce business does not do overseas 2C, but serves overseas small B buyers. 1688 is to help cross-border e-commerce buyers and sellers achieve more efficient supply and demand matching in an ecological way. For example, in cooperation with overseas independent stations, the products are directly laid on the independent stations by means of source-seeking communication. In addition, many large and medium-sized overseas buyers now have their own ERP systems, which will involve product inventory and supplier management. 1688 will be embedded in ERP based on their demands, and one-click distribution of goods will be carried out."

Specifically, 1688 is to turn China’s digital supply chain into a digital "chip"-like solution and capability that can be integrated, and then do cross-border cooperation, which is neither Apple mode nor Android mode, but more like Intel mode.

In the early days of cross-border e-commerce, cross-border e-commerceThe links are deep and long, and many links are impassable. Buyers find it hard to use, so they need to hire a Chinese agent or set up an office in China to find someone to choose goods on 1688. Now these links are open, and the interface is more friendly, turning into a digital "chip", plug and play.

When overseas buyers get the digital "chip", it is equivalent to getting the capacity of the whole China industrial belt, which is the largest digital assembly and digital supply chain supplied by the source. Buyers can also customize their needs. For example, if they choose Vietnam, 1688 will help them choose those supplies that meet the needs of Vietnam, recommend pallets that Vietnamese young people like, and provide supporting services for localized performance.

In the cross-border supply chain, 1688 is ready to export an integrated "supply chain solution", that is, a digital "chip" that integrates the white-label supply of China industries and can be "plug and play". Overseas buyers can only make inquiries on 1688 before, but now they can use AI to handle customs clearance, foreign exchange settlement, local distribution, and even the return and exchange of some key countries are done by 1688 and ecological partners. The core of "1688" is to help pallets go out to sea, with emphasis on the waist-high competitive and dynamic supply of China industries.

Cover/Figure Worm Creativity

(Source: Hugo Express)