12 questions about COVID-19 vaccine, look at the answers.

On the afternoon of March 28th, the State Council Joint Prevention and Control Mechanism held a press conference to introduce the vaccination and supply guarantee in COVID-19. As of March 27th, 2021, 102.417 million doses of Covid-19 vaccine have been reported in various places.

About COVID-19 vaccine, the conference also introduced these latest news.

1. What should I do if I am not sure if I am suitable for vaccination?

If it really belongs to the vaccination taboo, it is impossible to provide vaccination services. If it is listed in the vaccination items, it is recommended to tell the vaccination doctor truthfully before vaccination. So that doctors can fully evaluate and determine whether it is suitable for vaccination.

2. How long is the vaccine protection period?

COVID-19 vaccine is a new vaccine. According to the antibody level, it will be monitored for more than six months. But we also know that antibody is not the only protective indicator, and there are other factors in the process of vaccine’s function. Therefore, we should do relevant research on the persistence of the vaccine to confirm how long its protection period is.

3. I have been vaccinated with COVID-19 vaccine. Do I need to be vaccinated again?

According to Zhongsheng of Sinopharm, during the whole clinical research, it is now observed that the persistence of vaccine protection is about half a year, and the persistence of neutralizing antibodies is also about half a year. In the clinical process of the overall design, the booster needle was designed to observe the persistence and protection level of antibodies. At present, the preliminary results show that booster needle can effectively improve the titer of neutralizing antibodies, effectively improve the persistence of antibodies, and also effectively improve the anti-mutation ability of vaccines.

In the future, phase III clinical research will be carried out overseas to continuously observe the persistence of antibodies and protection. Is it necessary to carry out booster vaccination? When will you call? Still have to answer according to the results of the next three clinical studies.

4. What is the preventive effect of COVID-19 vaccine?

The vaccine itself can prevent infection, morbidity, severe illness and death. Now, the effectiveness result we get is the result of our clinical experiment. With the application of the vaccine, we will also carry out related research on its protective effect after marketing.

5. How to ensure the supply of vaccines in COVID-19?

On the one hand, actively and steadily expand the vaccination service capacity, optimize the vaccine distribution process, and improve the efficiency of circulation and operation. To scientifically arrange the turnover quantity of vaccines, the requirement is not to overstock the inventory, and to increase the number of inoculation points and inoculation stations in various ways to meet the vaccination needs of the masses. On the other hand, it is necessary to strengthen the linkage between departments and coordinate the industrial and information departments to strengthen the supply guarantee of vaccines.

6. After the first injection, how long is the best time to inject the second injection?

After the first dose of vaccination, the interval between the second dose of vaccination should be greater than or equal to three weeks, and the second dose of vaccination should be completed as soon as possible within 8 weeks after the first dose of vaccine.

7. If you catch up with a business trip or go out, can you get a second shot in a different place?

According to the guidelines, it is recommended to use the varieties of the same enterprise as much as possible to complete two doses of vaccination. If the same variety is not available in different places, then other vaccine products of the same kind can be replaced to complete two doses of vaccination.

Effective period

8. If I miss the second dose of vaccination for some reason, how can I make it up?

For those who have not completed 2 or 3 doses of COVID-19 vaccine according to the procedure, it is suggested to replant as soon as possible. There is no need to restart the immunization program, just replant and complete the corresponding dose.

9. Some vaccine developers have been vaccinated in February and March last year. What are the antibodies in these people?

Some people, as the vanguard of vaccines, have been vaccinated with inactivated vaccines in COVID-19. We are constantly monitoring the change data of antibodies in their bodies. At present, we have obtained the antibody monitoring data for 9 months. Judging from the current data, the antibodies in 9 months still have a certain level. We will continue to strengthen monitoring in the future.

10. Will foreign virus variation affect the effectiveness of existing vaccines?

Vaccine research and development units and production units pay great attention to dealing with the variation problem. Two inactivated vaccines of Sinopharm Group China Bio, using the serum after the second and third clinical trials at home and abroad, have carried out cross-comprehensive experiments on the strains found in South Africa and Britain, as well as more than 10 strains found in different regions and epidemic areas in China. The results show that neutralizing antibodies produced by the two inactivated vaccines have a good neutralizing effect on these strains. Small variation of the virus will not affect the antigenicity of the vaccine, that is, the vaccine will be effective without variation of protective antigen, especially the whole virus inactivated vaccine.

11. How to advance the national plan for vaccination of the elderly?

At present, Beijing, Shanghai and other regions have been vaccinated with Covid-19 vaccine for some elderly people over 60 years old and patients with chronic diseases who are willing to be vaccinated and in good physical condition under the premise of fully evaluating the health status and infection risk of the vaccinated objects. In the next step, we will actively and steadily promote the vaccination of people over 60 years old and patients with chronic diseases in combination with the use effect of vaccines in large-scale populations.

12. When will people under the age of 18 be vaccinated?

Last year, the phase I/II clinical research conducted by China Bio in Henan covered the systematic, safe and immunogenic clinical research of the young age group of 3-17 years old. At present, the safety data of this age group have been completely obtained, and the expected results have been achieved. The detection of immunogenicity and neutralizing antibodies has also been completed. We will communicate with the Food and Drug Administration in the near future, and I believe that this group of people can be covered in the near future.

(Source: Henan CDC)

Original title: "12 questions about COVID-19 vaccine, look at the answer"

Read the original text